Salmonella abortus

Antweller ( ) in 1961 injected Salmonella abortus equl and E. coll endotoxins Intraperltoneally into rats and looked for mast cells in the mesentery and the histamine content of the abdominal fluid. Negative results were obtained with amounts of the endotoxins (up to 10 yg) thought to be similar to that in cotton dust although large doses of endotoxin were known to cause rapid histamine release in cats and dogs. He concluded that endotoxins did not produce histamine release or the biological effect of cotton dust extracts. 

Several phase I trials have been performed with LPS from Salmonella abortus equi administered i.v. in patients who suffered from disseminated cancer. White blood cell number decreased after each injection and returned to basal level by 24 hours. There were no changes in coagulation parameters, and no disseminated intravascular coagulation was observed. After the first injection of LPS, increases in TNF-a concentration and IL-6 activity in serum were detected. However LPS tolerance which is accompanied by a decrease in TNF-a and IL-6 production depended on the intervals between repeated injections, but it was not determined whether it was a benefit or a draw-back. Injections of IFN-y prevented this decrease in TNF-a and IL-6, and ibuprofen attenuated LPS toxicity [183,186],... 

Dimmeler, S., Messmer, U. K., Tiegs, G., and BrUne, B. (1994). Modulation of glyceraldehyde-3-phosphate dehydrogenase in Salmonella abortus equi lipopolysaccharide-treated mice. Ear.. Pharmacol. 267, 105-112. 

Constit. of the lipopolysaccharides of Salmonella abortus equi and other Gram-negative organisms. 

Pathogens known to stimulate CSF production include Salmonella typhi-murium, Mycobacterium lepraemurium, Brucella abortus and Schistosoma mansonii. Additionally, non-viable bacteria or bacterial products, such as Nocardia rubra cell-wall fragments, muramyl peptides and bacterial endotoxins, can also induce CSF production. 

In addition to the kinds of activity enumerated above, the highly methoxylated bioflavonoids exhibit a rather strong antibacterial, antifungal, antiviral activity (82-86). The compounds have shown inhibitory activity against organisms such as E. coll, Typhi, Salmonella Typhi, Shigella Dysenteriae, Staphylococcus, B. Abortus Bang, influenza Virus A and rhinoviruses. Some of the compounds were active in concentrations as low as 2.5 pg per liter. 

By use of different extraction procedures, two types of lipopolysaccharides have been isolated from a slightly virulent strain of Yersinia pestis Some structural information was obtained from methylation and periodate oxidation studies. The immunodominant moiety of lipid A has been shown to consist of a residue of 2-amino-2-deoxy-D-glucose, A-acylated with 3-hydroxytetradecanoic acid. ° A lipopolysaccharide isolated from Y. enterolitica exhibits serological cross-reactions with lipopolysaccharides from Brucella abortus and Vibrio cholerae Common antigenic relationships between the lipopolysaccharides of Escherichia coli, Kloechera africana, and Salmonella aberdeen have been demonstrated. 

Little et al. (1950) have noted that a folio acid deficiency in young chicks inhibited the agglutinin response to Brucella abortus, Pasteurella muUocida, and Salmonella typhosa. The ability of vaccinated chicks to resist infection with P. muUocida was also impaired. 

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