Bioflavonoids methoxylated

Certain bioflavonoids may play a preventive role against cardiovascular diseases. Some citrus and other bioflavonoids have been demonstrated to reduce serum cholesterol levels and to affect fatty acid metabolism (70,71,72). The strong antiadhesive action on red cells and platelets of highly methoxylated flavones such as nobiletin, which also demonstrates antithrombogenic activity (73), indicates an important role in blood rheology and tissue perfusion. The antiadhesive action may indicate a preventive role in atherosclerosis since there is evidence that reduced perfusion of the vascular wall may interact with serum lipids to promote atherogenesis (74). 

In addition to the kinds of activity enumerated above, the highly methoxylated bioflavonoids exhibit a rather strong antibacterial, antifungal, antiviral activity (82-86). The compounds have shown inhibitory activity against organisms such as E. coll, Typhi, Salmonella Typhi, Shigella Dysenteriae, Staphylococcus, B. Abortus Bang, influenza Virus A and rhinoviruses. Some of the compounds were active in concentrations as low as 2.5 pg per liter. 

In the early work on bioflavonoids, citrus extracts were used, and later research has revealed the presence of highly active methoxylated flavones in citrus. The amount of these flavones recovered along with the more abundant hesperidin, naringin, eriodictyol varies with the methods of extraction and purification used. Thus, bioflavonoid preparations by the many workers may have varied widely in activity. 

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