Salicylic acid Jessner’s solution

Glycolic acid Jessner s solution Pyruvic acid Resorcinol Salicylic acid Trichloracetic acid Deep chemical peels... 

TCA 10-30% Tretinoin Salicylic Acid Glycolic Acid Jessner s Solution... 

Jessner s solution contains 14% resorcinol, 14% salicylic acid and 14% lactic acid. Jessner s solution has been used alone for superficial peeling, or in combination with TCA 35% to achieve a medium-depth peel. Increasing the number of coats applied to the treated area increases the depth and reaction induced by the Jessner s peel. These peels are well tolerated with minimal side effects in the author s practice. As with glycolic acid and salicylic acid peels, Jessner s peels are most commonly used as adjimctive therapy for moderate to severe facial dyschromias, acne, oily skin, texturally rough skin, fine wrinkles, and pseudofolliculitis barbae. 

Salicylic acid 20-30% Jessner s solution Glycolic acid 20,35,50,70% Trichloracetic acid 10-30%... 

Salicylic acid 20-30% Glycolic acid 70% Jessner s solution Pyruvic acid 40%... 

Jessner s Solution has been used for over 100 years as a therapeutic agent to treat hyperkera-totic epidermal lesions [1]. This superficial peeling agent constitutes a mixture of salicylic acid, resorcinol, and lactic acid in 95% ethanol. Jessner s solution causes loss of corneocyte cohesion and induces intercellular and intracellular edema. Jessner s typically induces wounding to the level of the papillary dermis. Historically, resorcinol (a key component of Jessner s peels) was used in concentrations of 10-50% in the early twentieth century. High concentrations of resorcinol were associated with side effects such as allergic contact dermatitis, irritant contact... 

Each component of Jessner s solution has specific effects (Fig. 3.1). Salicylic acid (ortho hydroxy benzoic acid) is a beta hydroxy acid agent... 

Comedonal acne Salicylic acid 25% Pyruvic acid 40-70% Jessner s solution Unna Paste Glycolic acid 70%... 

Salicylic acid 25-30% Pyruvic acid 40-60% Jessner s solution Unna Paste Pyruvic acid 40-60%... 

Salicylic acid 25% + trichloroacetic acid >25% Glycolic acid 70% + trichloroacetic acid 35% Jessner s solution+trichloroacetic acid 35% Phenol 88%... 

Ejaz A et al (2008) Comparison of 30% salicylic acid with Jessner s solution for superficial chemical peeling in epidermal melasma. J CoU Physicians Surg Pak 18 205-208... 

Grimes [11] compared the histologic alterations induced by a variety of chemical peels in 17 patients with skin types IV, V, and VI, including glycolic acid 70%, salicylic acid 30%, Jessner s solution, and 25% and 30% TCA. Peels were applied to 4 x 4 cm areas of the back and 2 x 2 cm postauricular sites. Biopsies were performed at 24 h (Fig. 21.2a-d). Glycolic acid induced the most significant stratum comeum necrosis. Compared to the other tested peels, salicylic acid and Jessner s peels caused mild lymphohistiocytic der-... 

The standard formulation of Jessner s solution contains resorcinol (14 g), salicylic acid (14 g), and lactic acid (85%, 14 g) mixed in a sufficient quantity of ethanol to make 100 ml. Modified Jessner s solution contains 17% lactic acid, 17% salicylic acid, and 8% citric acid mixed in a sufficient quantity of ethanol to make 100 ml. Solutions are available (Delasco, Pubmed). 

Combes (Jessner s) solution Resorcinol 14 g Salicylic acid 14 g Lactic acid 85 % 14 mL Ethanol 95 % 100 mL Trichloroacetic acid 10-25 %... 

Ejaz A, Raza N, Iftikhar N, Muzzafar F. Comparison of 30 % salicylic acid with Jessner s Solution for superficial chemiced peeling in epidermal melasma. J Coll Physicians Suig Pak. 2008 18 205-8. 

These include 10-15% trichloroacetic acid (TCA), alpha-hydroxy acid (AHA), beta-hydroxy acids such as salicylic acid, topical tretinoin, and one to two coats of Jessner s solution [14% resorcinol, 14% salicylic acid, 14% lactic acid, and ethanol). These peels penetrate the stratum corneum and possibly the upper layers of the stratum spinosum. Because of the very superficial depth of pene-... 

Light chemical peels include 20-35% TCA, 70% glycolic acid, and Jessner s solution (resorcinol, salicylic acid, lactic acid, and ethanol) and penetrate the entire epidermis. These peels are more effective than the very light peels for the treatment of actinic keratoses, solar lentigenes, and epidermal growths such as thin seborrheic keratoses. Skin texture may also be improved. Erythema and scaling will occur postoperatively however healing time is faster if... 

Jessner s solution, consisting of lactic acid, salicylic acid and resorcinol, is a mild peeling agent in its own right. However, it can serve as cleanser, degreaser and peel in one step. In this capacity, it is combined with TCA in a combination peel. 

Chemical peels can be classified by the depth of penetration into the skin (Table 9.2). Superficial peelings (epidermis to upper papillary dermis) are the most commonly used peels in all phototypes. These agents include tretinoin 1-5%, TCA 10-35%, glycolic acid solution 30-50% or glycolic gel 70%, salicylic acid 20-30% in ethanol and Jessner s solution (Combes formula). 

Jessner s solution contains 14% resorcinol, 14% salicylic acid and 14% lactic acid. It has been used alone for superficial peeling, or in combination with TCA 35% for medium-depth peeling. 

Jessner s solution 14% resoroinol, 14% salicylic acid and 14% lactic acid mixed in ethanol Obagi s blue peel base non-ionio blue dye, glycerin, saponin... 

In an attempt to speed the penetration and depth of TCA peels, two modified peels were created which incorporate the use of a keratolytic agent. Monheit described a Jessner s-TCA peel utilizing a keratolytic acid preparation, Jessner s solution, applied prior to the application of TCA. Jessner s solution is comprised of 14% each of resorcinol, salicylic add, and lactic acid mixed in ethanol. Application of the Jessner s solution allows for faster and deeper penetration of the subsequently applied 35% TCA. A similar mechanism is employed with Coleman s glycolic acid-TCA peel, which uses 70% glycolic acid, also acting as a keratolytic, prior to application of 35% TCA. 

Photoaging Wrinkle severity index +++Retinoic acid +++Trichloroacetic acid (TCA) 30% ++Glycolic acid ++Resorcinol ++Jessner s solution +Salicylic acid... 

Jessner s peel solution, formerly known as the Coombe s formula,was pioneered by Max Jessner, a dermatologist. Jessner combined 14% salicylic acid, 14% lactic acid, and 14% resorcinol in an ethanol base. It is thought to break intracellular bridges between keratinocytes. 

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