Rosacea azelaic acid

Carmichael AJ, Marks R, Graupe KA, Zaumseil RP (1993) Topical azelaic acid in the treatment of rosacea. J Dermatol Treat 4(81) 19-22... [Pg.198]

Elewski B, Fleischer AB, Pariser DM (2003) A comparison of 15% topical azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papu-lopustular facial rosacea results of a randomized trial. Arch Dermatol 139 1444-1450... [Pg.198]

Thiboutot D, Thieroff-Ekerdt R, Graupe K (2003) Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea results from 2 vehicle-controlled, randomized, phase III studies. J Am Acad Dermatol 48 836-845... [Pg.198]

Bjerke R, Fyrand O, Graupe K (1999) Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulopustular rosacea. Arch Derm Venereol 79 459-459... [Pg.198]

Azelaic acid Cream For the treatment of inflammatory papules and pustules of mild to moderate rosacea... [Pg.465]

Azelaic acid is a straight-chain saturated dicarboxylic acid that is effective in the treatment of acnevulgaris (in the form of Azelex) and acne rosacea (Finacea). Its mechanism of action has not been fully determined, but preliminary studies demonstrate antimicrobial activity against P acnes as well as in vitro inhibitory effects on the conversion of testosterone to dihydrotestosterone. Initial therapy is begun with once-daily applications of the 20% cream or 15% gel to the affected areas for 1 week and twice-daily applications thereafter. Most patients experience mild irritation with redness and dryness of the skin during the first week of treatment. Clinical improvement is noted in 6-8 weeks of continuous therapy. [Pg.1296]

Azelaic acid is an antibiotic agent that inhibits microbial cellular protein synthesis. It is indicated in the topical treatment of mild to moderate inflammatory acne vulgaris (cream) topical treatment of papules and pustules of mild to moderate rosacea. [Pg.96]

Azelaic acid (AA), 1,9-nonanedioic acid or heptane-1,7-dicarboxylic acid, is used in manifold application areas. AA is offered in the pharmaceutical field for the treatment of acne and rosacea due to its antibacterial effect [1,2]. However, AA is much more widely applied as a monomer for the production of polymers such as alkyd resins, polyamides, and impact-proof polyesters or for the synthesis of plasticizers, lubricants, lithium complex greases, corrosion inhibitors, dielectric fluids, heat-transfer fluids, metal to glass fluxes, emulsion breakers, waxes, tobacco sheet plasticizers, hot-melt coatings and adhesives, water-soluble coating resins, hydraulic fluids, fungicides, insecticides, and so on [3-7]. [Pg.331]

Rosacea prescribe topical products containing 2-3% pyruvic acid, or 1-2% salicyhc acid, or 0.05% tretinoin for 3 weeks before the procedure to reduce thickness of the stratum comeum and improve uniform penetration of the pymvic acid. This treatment should be intermpted 3 days before the procedure. Treatment with topical metronidazole or azelaic acid can be maintained. [Pg.26]

Azelaic acid is a saturated dicarboxylic acid. Its therapeutic effect in rosacea is likely based on the inhibition of the synthesis of reactive oxygen species by neutrophils. The efficacy of 15% azelaic acid gel is similar to that of 1% metronidazole gel [39, 40]. [Pg.161]

According to Cochrane [60], only metronidazole and azelaic acid showed to be effective in the topical treatment of rosacea. [Pg.162]

Literature data about the use of peelings in rosacea are very poor. This is due to the fact that peelings can induce worsening of the disease, prolonged erythema, and delayed healing [62]. However, in very selected cases, some patients with mild varieties of papulopustular rosacea can improve by means of peelings with salicylic acid, azelaic acid, and mandeUc add [63]. [Pg.162]

Elewski BE (2007) Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. Cutis 79 57-58... [Pg.164]

Liu RH, Smith MK, Basta SA, Farmer ER (2006) Azelaic acid in the treatment of papulopustular rosacea a systematic review of randomized controlled trials. Arch Dermatol 142 1047-1052... [Pg.164]

Draelos ZD (2004) Noxious sensory perceptions in patients with mild to moderate rosacea treated with azelaic acid 15% gel. Cutis 74 257-260... [Pg.164]

Rosacea Clinical evaluation +++ Salicylic acid +++Pyruvic acid +Azelaic acid... [Pg.124]

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