Role of neuropeptide

Yeadon, M., Wilkinson, D. and Payne, A.N. (1991b). Induction of trachea] plasma protein extravasation in the conscious guinea-pig by ozone role of neuropeptides. Br. J. Pharmacol. 102, 334P. 

The complexity of the pathobiology of anxiety disorders and the diversified treatment choices are further emphasized by the examination of the role of neuropeptides [NPs] in anxiety and their possible application as treatment modalities [see Tollefson, Chapter 26, in this volume]. More than 50 NPs have been identified many of them interact with conventional neurotransmitter systems as well as with each other. Some of them or their mimetics... 

Smith BN, Davis SF, van den Pol AN et al (2002) Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2. Neuroscience 115 707-14 Smith-White MA, Herzog H, Potter EK (2002) Role of neuropeptide Y Y2 receptors in modulation of cardiac parasympathetic neurotransmission. Regul Peptides 103 105-11 Stanford IM, Cooper Al (1999) Presynaptic mu and delta opioid receptor modulation of GABAa IPSCs in the rat globus pallidus in vitro. 1 Neurosci 19 4796 4803 Starke K (1977) Regulation of noradrenaline release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 77 1-124... 

The analysis of neuropeptides in insects may lead to the development of both specific insect control strategies and model systems that clarify the role of neuropeptides in all animals. Therefore it is important to vigorously pursue neuropeptide studies and to exploit the available technologies to the fullest. This paper will review the importance of current recombinant DNA techniques to the study of neuropeptide biology. Studies of the adipokinetic hormone (AKH) family will be emphasized as examples, but other peptides will be mentioned to present a broader picture of the advantages and problems associated with the techniques. 

Arneric SP, Holladay M, Williams M (2007) Neuronal nicotinic receptors a perspective on two decades of drug discovery research. Biochem Phtirmacol 74 1092-1101 Arora S, Anubhuti (2006) Role of neuropeptides in appetite regulation and obesity - A review. 

Arthur S. Edison obtained a B.S. in chemistry from the University of Utah, where he studied monoterpenes isolated from southern Utah sagebrush by NMR. He completed his Ph.D. in biophysics from the University of Wisconsin, Madison, where he developed and applied NMR methods for peptide and protein structural studies under the supervision of John Markley and Frank Weinhold. In 1993, Dr. Edison joined the laboratory of Anthony O. W. Stretton at the University of Wisconsin as a Jane Coffin Childs postdoctoral fellow where he investigated the role of neuropeptides in the nervous system of the parasitic nematode Ascaris suum. He joined the faculty at the University of Florida and the National High Magnetic Field Laboratory in 1996 and is currently the Director of Chemistry Biology at the NHMFL. Dr. Edison s current research is in technology development for high-sensitivity NMR and natural product discovery in nematodes and other invertebrates. Dr. Edison is the recipient of the 1997 American Heart Association Robert J. Boucek Award, a CAREER Award from the National Science Foundation in 1999, and, with his postdoctoral scientist Aaron Dossey, the Beal award for the best publication of the year in the Journal of Natural Products in 2007. 

Rettori, V., Milenkovic, L., Riedel, M. McCann, S.M. (1990b) Physiological role of neuropeptide Y (NPY) in control of anterior pituitary hormone release in the rat. Endocrinol. Exp. 24, 37-45. 

Morris, J.L. (1991) Roles of neuropeptide Y and noradrenaline in sympathetic neurotransmission to the thoracic vena cava and aorta of guinea-pigs. Regal. Pept. 32, 297-310. 

Ganten, D., Paul, M. Lang, R.E. (1991) The role of neuropeptides in cardiovascular regulation. Cardiovas. Drugs Therapy 5, 119-130. 

The advent of HPLC, especially in the reverse-phase mode, is now resulting in major advances in many areas of interest, not the least in our understanding of the role of neuropeptides in the CNS. 

There are still many problems to be overcome in this field before conclusions as to the role of neuropeptides in schizophrenia may be drawn. Is the medical diagnosis of the illness objective—would two independent physicians reach the same conclusion in each case Are we using true controls Since medical/ethical grounds prevent the removal of CSF except for medical reasons (quite rightly ), control CSF is obtained from... 

The role of neuropeptides and sensory and autonomic nerves in allergic rhinitis has been recently reviewed in detail (38,42). It is clear that neurogenic... 

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