Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ring three component

The polybenzoxazines (PBZs) provide a new class of phenolic resins that were first described by Ishida in 1998 (Ref. 15). Synthesis of the resins involves three components a phenol, a primary amine and formaldehyde. The first stage involves the formation of a multifunctional benzoxazine monomer Figure 23.30 a)). The monomer can then be ring-opened at elevated temperatures (160-220 C) to yield a polymeric stmcture (Figure 23.30(b)). [Pg.666]

Michael additions followed by further Michael additions have become popular reactions and are usually referred to as Michael Michael Induced Ring Closure (MIM1RC) reactions. A three component Michael-Michael-aldol reaction of ketone enolates with acrylates can be achieved, resulting in the formation of six-membered ring compounds with good efficiency and high diastereoselectivites319. [Pg.994]

After the components have been placed next to one another, drawing the final structure requires removal of the H2 O units. UMP has three components. From right to left in the drawing, they are uracil, a single-ring base ribose, the sugar and one phosphate group. [Pg.935]

A domino process based on the twofold addition of alkenyl anions to a squarate ester was used by Paquette and coworkers [96] for the total synthesis of the triqui-nane sesquiterpene hypnophilin (4-284). The three-component reaction of 4-281,4-282 and vinyl lithium gave primarily the trans- and cis-adducts A and B, which furnished D either by an electrocyclic ring opening/ring closure via C or a dianionic oxy-Cope rearrangement (Scheme 4.60). Further transformations led to E and F, which resulted in the formation of 4-283 on treatment with acid. [Pg.320]

A number of fused thiopyranopyrazolopyrimidines with potential as potassium channel openers have been prepared by a three-component Hantzsch-type reaction between a ketone, an aldehyde, and an aminopyrazole. These reactions give a mixture of isomers, with and without ring junction heteroatoms (Equation 49) <2002BML1481> among the compounds of particular interest are those in which the ketone is a derivative of thiopyran or its A,A-dioxide. [Pg.893]

A further neat example of multicomponent reactions in heterocyclic synthesis was reported by Ma et al. <06AG(E)7793>. They prepared the furan-fused 1,4-thiazepine 140 in good yield using the three components 137, 138, and 139 in the one reaction. A range of other furan-fused analogues with different substituent groups in the thiazepine ring were also synthesised. [Pg.457]

Another method for preparing pyrrole rings is by Ugi-type three-component condensation (Scheme 6.184). In the protocol published by Tye and Whittaker [345], levulinic acid was reacted with two different isonitriles and four amine building blocks (1.5 equivalents) to provide a set of eight pyrrole derivatives. While the previously published protocol at room temperature required a reaction time of up to 48 h and provided only moderate product yields, the microwave method (100 °C, 30 min) optimized by a Design of Experiments (DoE) approach (see Section 5.3.4), led to high yields of the desired lactams for most of the examples studied. [Pg.226]

Based on the established mechanism for titanium-catalyzed hydroamination, the authors propose a reversible reaction between a titanium imide complex and the alkyne to form metalloazacyclobutene 86, which in turn undergoes 1,1-insertion of the isonitrile into the Ti-C bond. The generated five-membered ring iminoacyl-amido complex 87 with the new C-C bond is protonated by the primary amine to afford the desired three-component coupling product, with regeneration of the catalytic imidotitanium species. Very recently, titanium-catalyzed carbon-carbon bond-forming reactions have been reviewed.122... [Pg.421]

As seen in Scheme 55, with the simple addition of a balloon of CO to the [5 + 2]-reaction of VCPs and alkynes or allenes, the [5 + 2]-reaction can be diverted via a nine-membered metallacycle to produce initially an eight-membered ring product. This Rh(l)-catalyzed three-component [5 + 2 + l]-reaction is mechanistically similar to the previously mentioned [6 + 2]-reaction (Section 10.13.2.5.2) differing only in regard to the insertion of CO in the pathway versus its incorporation in starting material (Scheme 56). [Pg.631]

Reaction between the 2-azadiene 253 and ethylenediamine results in the formation of both rings in the dihydro product 254 (Equation 48) <1996H(43)1943>. A three-component coupling between the thiourea derivative 255,... [Pg.574]

Reduced 5-oxo derivatives of ring system 68 have been prepared by reaction between an iV)./V-nitroketene acetal and cr-chloroisocyanates <2007S835>. Attempts to form examples of ring system 68 using the three-component coupling method referred to above result in zero or very low yields however by pre-forming an imine intermediate from the aminoheterocycle and the aldehyde, which is then reacted with the isonitrile component, satisfactory yields can be obtained <2007TL2213>. [Pg.580]

Yadav and Kapoor <2003TL8951> reported on a microwave-assisted ring closure leading to novel thiazolo[l,3,5]-triazines, as shown in Scheme 36. This three-component one-pot procedure started from the thiazolyl Schiff base 230, to which ammonium acetate and an aldehyde was added. In the first step, the azomethine moiety of the Schiff base reacted with ammonia to give the zwitterionic first intermediate 231, which underwent deprotonation to the amine 232, and, finally, reaction of this second intermediate with the aldehyde involving the ring-closure step afforded the product 233. It is important to emphasize that the MW-assisted technique ensured high yields (76-88%)... [Pg.989]

Steroids are the only common lipids without fatty acids. Chemically, they consist of a fused carbon ring structure consisting of four rings, three rings of which are six membered and one ring of which is five membered, as shown in Figure 16.5. Some steroids, such as cortisone, function as hormones. Cholesterol is an important component of membranes in animal cells. [Pg.468]


See other pages where Ring three component is mentioned: [Pg.101]    [Pg.101]    [Pg.94]    [Pg.103]    [Pg.184]    [Pg.466]    [Pg.96]    [Pg.116]    [Pg.257]    [Pg.206]    [Pg.934]    [Pg.388]    [Pg.472]    [Pg.527]    [Pg.555]    [Pg.577]    [Pg.59]    [Pg.98]    [Pg.906]    [Pg.36]    [Pg.97]    [Pg.156]    [Pg.226]    [Pg.228]    [Pg.296]    [Pg.549]    [Pg.155]    [Pg.613]    [Pg.466]    [Pg.563]    [Pg.568]    [Pg.570]    [Pg.572]    [Pg.579]    [Pg.580]    [Pg.998]    [Pg.87]   
See also in sourсe #XX -- [ Pg.53 ]




SEARCH



Three component ring transformation

Three-component

© 2024 chempedia.info