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Rings reactions

The reasons for this apparent polywalent activity toward nitrosation (N ring reaction, N exocyclic reaction, nitrosation on the 5-position) are not... [Pg.67]

Aromatic Ring Reactions. In the presence of an iodine catalyst chlorination of benzyl chloride yields a mixture consisting mostly of the ortho and para compounds. With strong Lewis acid catalysts such as ferric chloride, chlorination is accompanied by self-condensation. Nitration of benzyl chloride with nitric acid in acetic anhydride gives an isomeric mixture containing about 33% ortho, 15% meta, and 52% para isomers (27) with benzal chloride, a mixture containing 23% ortho, 34% meta, and 43% para nitrobenzal chlorides is obtained. [Pg.59]

As the bielectrophile contains two atoms of the five-membered ring, reactions to be considered under this category require a 1,3-binucleophile (see Table 1). An appreciable number of applications have been reported in the literature and illustrative examples are described below. One should also consider reactions discussed in Section 4.03.2.2 above as extensions of this concept. [Pg.129]

Furazano[3,4-/]quinoxaline, 7,8-diphenyl-synthesis, 6, 412 Furazanothiophene synthesis, 6, 417 Furazans, 6, 393-426 biological activity, 6, 425 bond angles, 6, 396 bond lengths, 6, 396 coordination compounds, 6, 403 diamagnetic susceptibilities, 6, 395 dipole moments, 6, 395, 400 heats of combustion, 6, 400 heterocyclic ring reactions, 6, 400-403 IR spectra, 6, 398 isoxazoles from, 6, 81 mass spectra, 6, 399 microwave spectroscopy, 6, 395, 396 MO calculations, 6, 395 monosubstituted... [Pg.636]

It is therefore not unexpected to find a similar effect in a heterocycle fused to a benzene ring. Reaction of the substituted benzothiazole, 71, with sodium hypochlorite in a mixture of sodium hydroxide and ammonia affords the sulfenamide, 72, probably by the intermediacy of the sulfenyl chloride. [Pg.326]

Reactions 11-15-11-18 are direct formylations of the ring. Reaction 11-14 has not been used for formylation, since neither formic anhydride nor formyl chloride is stable at ordinary temperatures. Formyl chloride has been shown to be stable in chloroform solution for 1 h at -60°C, but it is not useful for formylating aromatic rings under these conditions. Formic anhydride has been prepared in solution, but has not been isolated.Mixed anhydrides of formic and other acids are known and can be used to formylate amines (see 10-56) and alcohols, but no formylation takes place when they are applied to aromatic rings. See 13-15 for a nucleophilic method for the formylation of aromatic rings. [Pg.714]

Sealing Polymer O-rings Reaction platelet thickness 1.2 mm... [Pg.409]

Figure 1.43 indicates major sites of reactivity within the ring structures for nucleophilic displacement reactions. Cytosine, thymine, and uracil all react toward nucleophilic attack at the same two sites, the C-4 and C-6 positions. The presence of powerful nucleophiles, even at neutral pH, can lead to significant base modification or cleavage with pyrimidine residues (Debye, 1947). For instance, hydrazine spontaneously adds to the 5,6-double bond, initiating further ring reactions,... [Pg.54]

Yields are variable, but the reaction appears to be promoted by the presence of alkoxymethyl substituents on the oxirane ring. Reactions with p-propiolactones give lower yields (<10%). Cyclic carbonates can also be obtained from the zinc(II) promoted reaction of oxiranes with carbon dioxide [62] the stereochemistry of substituents on the oxirane are retained in the carbonate. [Pg.99]

Intramolecular hydrosilylation of the higher homologues 15 and 20 under similar conditions gave also excellent yields of cyclized products [5]. The homo-allyloxysilanes 15 afforded a mixture of six- and five-membered ring products in a ratio of 4.5 1 for R = Me and 2.5 1 for R = Ph in favour of the larger ring (Reaction 6.4). The EPR spectra obtained by the reaction of t-BuO radical... [Pg.122]

Oxidation of ketone phenylhydrazones generates a radical-cation centre on the nitrogen atom adjacent to the benzene ring. The radical-cation is delocalised by both the hydrazone group and the phenyl ring. Reactions of 1,3,5-triphenyl-A -pyazolines illustrate the properties of these radical-cations. Two one-electron waves are seen at a rotating disc electrode in acetonitrile and for 1,3.5-triphenyl-pyrazoline, Ey. = 0.82 and 1.68 V vs. see [33]. The delocalised radical-cation is... [Pg.308]

And so the enthalpy of formation of gaseous l-aza-2,8-dioxabicyclo[3.3.0]octane is predicted to be —10 kJmoL. Consider the 1-ring to 2-ring reaction in equation 18 and its associated exothermicity of 24 kJmoL. ... [Pg.61]

Several 1,2,4-trioxolanes are known which contain a double bond linked in some way to the ring, with interest focusing on furan endoperoxides. The alkene moiety of 2,5-dimethylfuran endoperoxide (41) can be selectively functionalized in the presence of the 1,2,4-trioxolane ring. Reaction with diimide gives the saturated ozonide <81TL3509> and a single addition product was obtained with p-nitrophenylazide, although the stereochemistry of the reaction was not determined. [Pg.601]

Regarding TP, the six-membered ring in most reactions behaves like a pyrimidine for the five-membered ring, reactions analogous to those of triazole are known. [Pg.109]

A recent halogen-free benzofuran that shares many structural features with its predecessor shows activity in controlling arrythmias. The synthesis starts with an unusual scheme for building the furan ring. Reaction of the benzyl bromide (2-1) with triphenylphosphine leads to phosphonium salt (2-2). Treatment of the salt with valeryl chloride in the presence of pyridine results in acylation on the now highly activated benzylic carbon (2-3). That product cyclizes to the benzofuran (2-4) on heating with expulsion of triphenylphosphine. Friedel-Crafts acylation of (2-4) with anisoyl chloride in the presence of stannic chloride proceeds on the... [Pg.384]

The other major approach to triazolo[4,3-a]pyridines is from pyridines or from 2-halogenopyridines, with the addition of a three-atom fragment to form the triazole ring. Reaction between pyridine or 4-methylpyridine and... [Pg.99]


See other pages where Rings reactions is mentioned: [Pg.131]    [Pg.243]    [Pg.530]    [Pg.549]    [Pg.550]    [Pg.219]    [Pg.35]    [Pg.129]    [Pg.996]    [Pg.274]    [Pg.695]    [Pg.278]    [Pg.407]    [Pg.95]    [Pg.114]    [Pg.435]    [Pg.115]    [Pg.53]    [Pg.333]    [Pg.138]    [Pg.996]    [Pg.98]    [Pg.272]    [Pg.294]    [Pg.403]    [Pg.465]    [Pg.584]    [Pg.425]    [Pg.451]    [Pg.167]    [Pg.126]    [Pg.123]   
See also in sourсe #XX -- [ Pg.170 ]




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