Rifampin interactions

Holtbecker N, Fromm MF, Kroemer HK, Ohnhaus EE, Heidemann H. The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism. Drug Metab Dispos 1996 24(10) 1121-1123. 

Correct choice = C. Rifampin interacts with the p-subunit of bacterial DNA-dependent RNA polymerase and thereby inhibits RNA synthesis. Because of the rapid emergence of resistant strains, rifampin is never given as a single agent. 

Gault H, Longerich L, Dawe M, Fine A. Digoxin-rifampin interaction. Clin Pharmacol Ther 1984 35(6) 750. ... 

Twum-Barima Y, Carruthers SG. Quinidine-rifampin interaction. N Engl J Med 1981 304(24) 1466-9. 

Casner PR. Inability to attain oral anticoagulation warfarin-rifampin interaction revisited. South Med J 1996 89(12) 1200-3. 

Oral contraceptive-rifampin interactions, leading to the breakthrough bleeding and contraceptive failure... 

Cyclosporin and rifampin interaction, leading to rejection of transplanted organs... 

Colmenero, J.D. Ferndndez-Gallardo, L.C. Agundez, J.A.G. Sedeno, J. Benitez, J. Valverde, E. Possible implications of doxycycline-rifampin interaction for treatment of brucellosis. Antimicrob.Agents Chemother., 1994, 38, 2798-2802 [extracted rifampin plasma serum papaverine (IS) LOQ 200 n mL]... 

Schwartz A, Brown JR. Quinidine-rifampin interaction. Am Heart J 9S4) 107,789-90. 

Barbarash RA. Verapamil-rifampin interaction. Drugintell Clin Pharm (1985) 19, 559-60. 

Zelunka EJ. Intravenous cyclosporine-rifampin interaction in a pediatric bone marrow transplant recipient. Pharmacotherapy (2002) 22, 387-90. 

Brocks DR, Lee KC, Weppler CP, Tam YK. Theophylline-rifampin interaction in a pediatric patient. ClinPharm (1986) 5, 602-4. 

Phenytoin interacts widi many different drugp. For example isoniazid, chloramphenicol, sulfonamides, benzodiazepines, succinimides, and cimetidine all increase phenytoin blood levels. The barbiturates, rifampin, theophylline, and warfarin decrease phenytoin blood levels. When administering the hydantoins with meperidine, die analgesic effect of meperidine is decreased. 

Rifabutin Adults0 5 mg/kg (300 mg) Children Appropriate dosing unknown Hematologic toxicity, uveitis, gastrointestinal symptoms, polyarthralgias, hepatotoxicity, pseudojaundice (skin discoloration with normal bilirubin), rash, flulike syndrome, orange discoloration of bodily fluids (sputum, urine, sweat, tears) Drug interactions are less problematic than rifampin... 

Rifampin Hepatic abnormalities monitor LFTs Reddish-orange discoloration of secretions (e.g., urine, sweat, tears) Potent inducer of CYP-mediated metabolism evaluate for drug-drug interactions... 

Oral azoles are associated with significant interactions, particularly due to cytochrome P-450 isoenzymes. Medications that interact with azoles include warfarin, phenytoin, theophylline, rifampin, cyclosporine, and zidovudine. For patients receiving only a few doses, these interactions do not pose a significant risk. These interactions may pose a risk for patients receiving long-term suppressive therapy for recurrent infections. 

Rifampin (RIF) 600 mg daily for 4 months can be used when INH resistance is suspected or when the patient cannot tolerate INH. Rifabutin 300 mg daily may be substituted for RIF for patients at high risk of drug interactions. 

Ramelteon is affected by alcohol, azole antifungals, fluvoxamine, and rifampin. Drug/Food interactions Ramelteon should not be taken with or immediately after a high-fat meal. 

Drugs that may interact with terbinafine include the following Cimetidine, rifampin, terfenadine, caffeine, dextromethorphan, cyclosporine. 

Drugs that may interact with isoniazid include acetaminophen, carbamazepine, chlorzoxazone, disulfiram, enflurane, hydantoins, ketoconazole, rifampin, and theophylline. 

Pharmacology Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase, but does not inhibit the mammalian enzyme. Cross-resistance has only been shown with other rifamycins. Rifampin at therapeutic levels has demonstrated bactericidal activity against intracellular and extracellular Mycobacterium tuberculosis organisms. Pharmacokinetics ... 

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