Ribose, synthesis

Researchers found that NAD serves as a substrate in poly(ADP-ribose) synthesis, a reaction important for DNA repair processes. In addition, it takes part in mono (ADP-ribosyl)ation reactions that are involved in endogenous regulation of many aspects of signal transduction and membrane trafficking in eukaryotic cells. 

Prebiotic ribose synthesis a critical analysis. Orig. Life Evol. Biosph., 18, 71-85. 

A. Fleetwood and V. Hughes, Convenient synthesis of 2,3-0-isopropylidene-5-thio-D-ribose and 5-thio-D-ribose synthesis of l,4-anhydro-2,3-0-isopropylidene-u-D-ribo-pyranose and l,4-anhydro-2,3-0-isopropylidene-5-thio-u-D-ribopyranose, Carhohydr. Res., 317 (1999) 204-209. 

Galione A, White A, Willmott N et al (1993) cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature 365 456-9... 

Shapiro, R. 1988. Prebiotic ribose synthesis. A critical analysis. Origins life Evol. Biosph. 18 71-85. 

Benjamin RC, Gill DM. 1980. Poly (ADP-ribose) synthesis in vitro programmed by damaged DNA a comparison of DNA molecules containing different types of strand breaks. J. Biol. Chem. 255 10502-8... 

As there are no reports of adverse effects from consumption of excess thiamine from food and supplements (supplements of 50 mg/day are widely available without prescription), and the data are inadequate for a quantitative risk assessment, no UL has been defined for thiamine. However, as stimulators of transketolase enzyme synthesis such as thiamine support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation, some concern has been expressed that thiamine supplementation of common food products may contribute to increased cancer rates in the Western world. There is, however, littie evidence to support this assumption. Rarely, individuals given high-dose intravenous thiamine in treatment of beriberi have developed anaphylaxis, the frequency being about 1 100,000. 

H6. Hiatt, H. H., Studies of ribose metabolism. II. A method for the study of ribose synthesis in vivo. J. Biol. Chem. 229, 725-730 (1957). 

R. Shapiro. Prebiotic ribose synthesis, a critical analysis. Origins of Life and Evolution of Biospheres, 18 (1988), 71-85. 

The poly(ADP-ribose) metabolism arising from the cooperation of PARP-1 and PARC is involved in DNA base excision repair and in DNA dama s naling to cell survival/cell death pathways. The present review focuses on a particular aspect of poly(ADP-ribose) signaling when PARP-1 is activated, it catalyzes poIy(ADP-ribose) synthesis on itself ( automodification). The polymers on PARP-1 can then recruit other proteins into multiprotein complexes and reprogram their domain functions. 

Satoh MS, Poirier GG, Lindhal T. Dual funcuon for poly(ADP-ribose) synthesis in response to DNA strand breakage. Biochemistry 1994 33 7099-7106. 

Donzelli M, Negri C, Mandarino A et al. Poly(ADP-ribose) synthesis A useful parameter for identifying apoptotic cells. Histochem J 1997 29(ll-12) 831-837. 

---