Retinoids clinical applications

Volume 190. Retinoids (Part B Cell Differentiation and Clinical Applications) Edited by Lester Packer... 

M. A. Livrea and G. Vidali, eds.. Retinoids From Basic S cience to Clinical Applications, Bitkhauser Vedag, Germany, 1994. 

Crouch, R.K. and J.-X. Ma. The role of vitamin A in visual transduction. In Vitamin A and Retinoids Am Update of Biological Aspects and Clinical Applications, edited by M.A. Livrea, Boston, Birkhauser Verlag, pp. 59-72, 2000. 

Kagechika H, Shudo K. Retinoids. Vitamin A for clinical applications. Farumashia 26, 35, 1990. 

Research on vitamin A and retinoids has a very long history, yet major advances are continuously in progress in this field. As we approach the new century, these molecules still are at the center of many different interests, from basic chemical, biochemical and cell biology research, to nutritional aspects and clinical applications. This book presents current knowledge and state-of-the-art information on research in many areas of this huge field of studies. Prominent scientists contributed chapters on the role of vitamin A in nutrition and the metabolism of retinol and retinoic acid, retinoic acid receptors and the interplay with vitamin D, the cell biology of retinoids and their role in the immune system. New synthetic molecules and their use in pharmacology and therapeutics are treated, and the importance of retinoids in the chnical practice of neoplastic and skin diseases is also covered. 

Vitamin A and retinoids an update of biological aspects and clinical applications M.A. Livrea (ed.)... 

Ross AC, Zhao Z, Arora D, Pasatiempo AMG, Kinoshita M, Gardner EM, Sri Kantha S, Taylor CE (1994) Retinoids in specific and nonspecific immunity studies on antibody production and natural killer cells. In MA Livrea, G Vidali (eds) Retinoids from basic science to clinical applications. Birkhauser, Basel, 197-213... 

Carlberg C, Saurat J-H (1996) Vitamin D3-retinoids association molecular basis and clinical application. 

Hinds, T. S., West, W. L., and Knight, E. M. (1997). Carotenoids and retinoids A review of research, clinical, and public health applications. /. Clin. Pharmacol. 37,551-558. 

For early clinical trials, where it is unlikely there will be full reproductive toxicology data, any application should include a discussion of whether any effects on reproduction can be anticipated from the primary pharmacodynamics. The nature of the target receptor binding and any potential for binding to receptors involved in reproduction should be considered. For compounds in classes already known to be teratogenic such as cytotoxic anticancer products, retinoids, or histone deacetylase inhibitors, it can be reasonably expected that... 

There is now compelling evidence from the number of retinoids in the clinic and in clinical studies (Table 12.1) that these molecules exhibit efficacy in human diseases. The use of ATRA for the treatment of acute promyelocytic leukemia is considered a successful therapy in our view. It is the hope that the application of retinoids, most probably more receptor specific retinoids/rexinoids, in combination with other chemotherapeutic agents, will lead to broad clinical utility in many diseases. We anticipate that the retinoid field will continue to expand as researchers gain more information about new levels of retinoid/rexinoid biology and their relevance to human diseases. 

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