Retinoblastoma tumor suppressor

Sauerbrey, A., Stammler, G., Zintl, F., and Volm, M., Expression and prognostic value of the retinoblastoma tumor suppressor gene (RB-1) in childhood acute lymphoblastic leukemia. Br.J. 

AHR with pRB, the product of the retinoblastoma tumor suppressor gene ... 

Merson, R.R., S.I. Karchner and M.E. Hahn. Interaction of the aryl hydrocarbon receptor and the retinoblastoma tumor suppressor gene product in the Atlantic killifish (Fundulus heteroclitus). Mar. Environ. Res. 54 409-410, 2002, Abstract. 

Rotchell, J.M., E. Unal, R.J. Van Beneden and G.K. Ostrander. Induction of retinoblastoma tumor suppressor gene mutations in chemically-induced liver tumors in medaka (Oryzias latipes). Mar. Biotechnol. 3 S44-S49, 2001. 

Similar to two-hybrid screens, SPRi can be used to detect conditions under which proteins do not interact. The interaction of human papillomavirus E7 protein and retinoblastoma tumor suppressor protein RB was studied by Jung and co-workers [49]. Fifteen hundred protein spots containing immobilized E7 protein were produced, and an interaction with added RB protein was detected using SPR. The addition of a peptide derived from a motif on E7 along with RB has been observed to clearly disrupt the interaction through lack of an SPR signal. The one peptide discussed in this study can easily be replaced with an array of... 

Cryns VL, Thor A, Xu H-J, et al. Loss of the retinoblastoma tumor suppressor gene in parathyroid carcinoma. N Engl J Med. 1994 330 757-761. 

Wang, J. Y, Naderi, S., and Chen, T. T. (2001). Role of retinoblastoma tumor suppressor protein in DNA damage response. Acta Oncol. 40, 689-695. 

Bradley JS, Olson C, Oberholzer M, Lin Y, Zones JM, Kohll HS, Bisova K, Fang S-C, Meisenheider J, Hunter T, Umen JG. Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. Plant Cell. 2010 22 3331-47. 

Hellmann A. Key elements of the retinoblastoma tumor suppressor pathway in Volvox carteri. Common Integr Biol. 2009 2 396-9. 

Khosravi-Far R, Esposti MD (2004) Death receptor signals to mitochondria. Cancer Biol Ther 3 1051 -1057 Kim R et al (2006) Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57 545-553 Kipreos ET, Wang JY (1990) Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science 248 217-220 Knudsen ES, Knudsen KE (2006) Retinoblastoma tumor suppressor where cancer meets the cell cycle. Exp Biol Med (Maywood) 231 1271-1281... 

A second example of inherited predisposition to cancer is provided by hereditary retinoblastoma. This is a rare tumor of the retina and, when it develops, it generally develops in one eye only. Nonetheless, in children with hereditary retinoblastoma, the cancer develops early in life and generally in both eyes. This is a striking example of the inherited predisposition to develop a tumor. As in the case of hereditary polyposis, the defect is in a tumor suppressor gene, in this case RBI. Here too patients have just one intact gene in each of their cells and a single mutation in that gene may be aU that is required to initiate tumor development. 

One of the most important of the tumor suppressor genes is Rb. Mutant Rb genes are found in many human tumors, including retinoblastoma (as cited earlier). The Rb protein is a potent inhibitor of cell division. Loss of Rb function will lead to abnormal cell division and, ultimately, to cell transformation. 

Dominant effect at the cellular level of a recessively inherited loss-of-function mutant of a tumor suppressor gene (see Chapter 14) Retinoblastoma and RBI Li-Fraumeni syndrome and TP53... 

Figure 14-7. Possible mechanisms for loss of heterozygosity at a tumor suppressor locus. All these mechanisms have been observed in retinoblastoma involving the RBI gene on chromosome 13.

Patients with retinoblastoma suffer from a high incidence of tumors arising from clonal outgrowth of some retinal precursor cells due to mutation of the tumor suppressor gene RBI. Analysis of cells from these tumors indicates that both copies of the RBI gene are mutated or lost, whereas the surrounding retinal cells have at least one functional RBI allele. 

It has been reported that the myc amino-terminal and central regions can specifically interact with the retinoblastoma (RB) tumor suppressor protein in vitro. This finding prompts the suggestion that RB may directly facilitate myc function, but it is not yet known whether the observed interaction reflects a physiologically relevant association in vivo. 

Y4. Yeh, S., Miyamoto, H., Nishimura, K., Kang, H., Ludlow, J., et al., Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem. Biophys. Res. Commun. 248, 361-367 (1998). 

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