Differential phosphorylation

SI. Mnsil, L. S., Cunningham, B. A., Edelman, G. M. and Goodenongh, D.. A. (1990). Differential phosphorylation of the gap jnnetion protein conncxin43 in junctional commnnicarlon-compe-tent and -deficient cell lines. J. Cell Biol. 111(5, pr. 1), 2077-2088. 

Musil LS et al. 1990. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol 111 2077-2088. 

Kipreos, E. T., and Wang, J. Y. J. (1990). Differential phosphorylation of c-abl in cell cycle determined by cdc2 kinase and phophatase activity. Science 248 217-220. 

Krek, W and Nigg, E. A. (1991a). Differential phosphorylation of vertebrate p34c 2 kinase at the Gl/S and G2/M transtitions of the cell cycle identification of major phosphorylation sites. EMBO J. 10 305-316. 

Maestes, D. C., Potter, R. M., and Prossnitz, E. R. (1999) Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J. Biol. Chem. 274, 29791-29795. 

Payne, J.M. Dahmus, M.E. Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit Ila. J. Biol. Chem., 268, 80-87 (1993)... 

Hepp R, Cabaniols JP, Roche PA (2002) Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A. FEBS Lett 532 52-56 Herrero I, Sanchez-Prieto J (1996) cAMP-dependent facilitation of glutamate release by beta-adrenergic receptors in cerebrocortical nerve terminals. J Biol Chem 271 30554-60 Heximer SP, Watson N, Linder ME et al (1997) RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci USA 94 14389-93... 

Quinton TM, Brown KD, Dean WL. inositol 1.4.5-trisphoqd>t4e-mediated Ca release from platdet internal membranes is regulated by differential phosphorylation. Biochemistry 3S 6865-6871 1996. 

As discussed in relation to protein phosphorylation (Ch. 19.3), substoichiometric changes in PTM such as phosphorylation may occru, demanding for a strategy to enable temporal monitoring of differential phosphorylation as a function of (potentially unknown) external or internal stimuli. In fact, some PTM may be disease-related, but others may not. Alternatively, several disease states are related to single amino-acid polymorphism. The state difference may not necessarily be expressed at protein level, but rather in different concentration(s) of small molecules. This is where metabolomics comes into play. 

IL-2 often synergizes with other cytokines (notably IL-12) to induce IFNy production by NK cells and to increase cytotoxicity by NK and LAK cells. The expression of the receptor for this cytokine on NK cells is, however, continuous in character, but only a very small percentage of these cells have receptors of great affinity. The study of differential use of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human NK cells by IL-2, IL-12, and IFNa has demonstrated a differential phosphorylation and consequent differential activation of both separate and overlapping STAT proteins by IL-2, IL-12, and IFNa. This may provide a molecular basis for the similarities and differences in the actions of these cytokines on NK cells. ... 

Cadrin, M., McFarlane-Anderson, N., Aasheim, L.H., Kawahara, H., Franks, D.J., Marceau, N. French, S.W. (1992) Cell. Signal 4, 715-722. Differential phosphorylation of CK8 and CKI8 by 12-0-tetradecanoyl-phorbol-13-acetate in primary cultures of mouse hepatocytes. 

Astier A, Manie SN, Avraham H, Hirai H, Law SF, Zhang Y, Golemis EA, Fu Y, Druker BJ, Haghayeghi N, Freedman AS, Avraham S. 1997. The related adhesion focal tyrosine kinase differentially phosphorylates pl30Cas and the Cas-like protein, pl05HEFl. J Biol Chem 272(32) 19719-19724. 

Kinsey WH. 1995. Differential phosphorylation of a 57-KE>a protein tyrosine kinase during egg activation. Biochem Biophys Res Commun 208(l) 204-209. 

Khosravi-Far R, Esposti MD (2004) Death receptor signals to mitochondria. Cancer Biol Ther 3 1051 -1057 Kim R et al (2006) Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57 545-553 Kipreos ET, Wang JY (1990) Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science 248 217-220 Knudsen ES, Knudsen KE (2006) Retinoblastoma tumor suppressor where cancer meets the cell cycle. Exp Biol Med (Maywood) 231 1271-1281... 

Figure 12.6 The use of DNA chromatography in the resolution of differentially phosphorylated oligodeoxynucleotides under denaturing conditions. The difference in polarity between the two species is clearly sufficient to resolve the strands, which may be up to 50 to 100...

J. A. Fyfe. Differential phosphorylation of ( )-5-(2-bromovinyl)-2 -deoxyuridine monophosphate by... 

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