Glutathione-responsive drug delivery

Figure 42.7 Depiction of the performance of glutathione, disulfide bonds are reduced to a glutathione-responsive drug delivery system thiol groups, which causes the uncapping of consisting of MSNPs capped with PEG through pores and triggers payload release [131], disulfide bonds. In the presence of...

In a study, polymeric nanoparticles (NPs) composed of a new redox-responsive polymer, poly(ethylene glycol]-b-poly(lactic acid] [MPEG-SS-PLA], were prepared to carry paclitaxel [PTX] for glutathione (GSH]-regulated drug delivery. The PTX-loaded MPEG-SS-PLA NPs were fabricated using an optimized oil-in-water emulsion/solvent evaporation method. The HPLC results revealed that the NPs released almost 90% PTX within 96 h when GSH presented at intracellular concentrations, whereas only a very small PTX amount was released at plasma GSH levels. The MTT assay results show that the NPs caused concentration- and time-... 

Bulmus V, Woodward M, Lin L, Murthy N, Stayton P, Hoffman A (2003) A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J Control Release 93 105-120... 

---