Response, structural analysis

Develop final Perform structural design of analysis of component acceptable accuracy Determine structural response—stresses, support reactions, deflections, and stability—based on a structural analysis of acceptable accuracy. Determine acceptable accuracy based on economic value of component, consequences of failure, state-of-the-art capability in stress and stability analysis, margin of safety, knowledge about loads and materials properties, conservatism of loads, provisions for further evaluation by prototype testing... 

Majeau, G.R. et al., Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice, J. Immunol., 152, 2753, 1994. 

From the X-ray structural analysis of the starting thionocarbamate 3b, the distance between the thiocarbonyl sulfur atom and the alkenyl carbon and between the thiocarbonyl carbon and the alkenyl carbon is 4.69 and 3.00 A, respectively. The fact that the reaction proceeded under these restricted conditions, in which the distance of each reacting site is longer than the sum of the van der Waals radii (3.5 A), is accounted for by the fact that the initial reaction occurred in the defect of the crystalline lattice, with the later reaction occurring in increasingly defective regions. Furthermore, two plausible factors are responsible for the relatively low enantiomeric excess of 3b. 

Response Surface Analysis Structure-Activity Relationship Superfund Amendments and Reauthorization Act Scientific Committee on Consumer Products Sister Chromatid Exchange... 

Structural analysis of the solid rocket case-grain system using experimentally determined propellant response properties may permit a complete description of the combined stresses and resultant deformations, but a statement expressing the ability of the propellant to withstand these stresses is also required. Such a statement, which relates the physical state at which failure occurs to some material parameters, is called a failure criterion. The criterion for failure permits a prediction of safety margins expected under motor operation and handling and defines the loading regimes where abnormal operations will occur with intolerable frequency. 

It appears that the formal theories are not sufficiently sensitive to structure to be of much help in dealing with linear viscoelastic response Williams analysis is the most complete theory available, and yet even here a dimensional analysis is required to find a form for the pair correlation function. Moreover, molecular weight dependence in the resulting viscosity expression [Eq. (6.11)] is much too weak to represent behavior even at moderate concentrations. Williams suggests that the combination of variables in Eq. (6.11) may furnish theoretical support correlations of the form tj0 = f c rjj) at moderate concentrations (cf. Section 5). However the weakness of the predicted dependence compared to experiment and the somewhat arbitrary nature of the dimensional analysis makes the suggestion rather questionable. 

The importance of crosslinked polymers, since the discovery of cured phenolic formaldehyde resins and vulcanized rubber, has significantly grown. Simultaneously, the understanding of the mechanism of network formation, the chemical structure of crosslinked systems and the motional properties at the molecular level, which are responsible for the macroscopic physical and mechanical properties, did not accompany the rapid growth of their commercial production. The insolubility of polymer networks made impossible the structural analysis by NMR techniques, although some studies had been made on the swollen crosslinked polymers. 

Structural analysis of LOS from a mutant of Xcc defective in core completion revealed that this mutant had modifications in the lipid A moiety, which had reduced acylation and was further derivatised with phosphoryl ethanolamine residues (Dow et al., 1995 Silipo et al., 2008). These changes in lipid A structure abolished the ability to trigger innate immune responses in Arabidopsis (Silipo et al., 2008). Importantly these findings indicate that Xcc has the capacity to modify the structure of its lipid A to reduce its activity as a MAMP in plants (Silipo et al., 2008). It is not known whether these (or other) modifications to lipid A occur when bacteria are within plants. 

The reduced form of RNR reacts with dioxygen to generate the p-oxo diferric core (crystallographically defined (3)) and a tyrosyl radical necessary for the production of a reactive species responsible for the reduction of ribonucleotides. The intimate details of this dioxygen-based chemistry and the structure of the reduced enzyme are still unknown. Despite intensive spectroscopic characterization of the active site of MMO and the recent X-ray structural analysis of the hydroxylase component (4), even less is known concerning its mechanistic pathways responsible for the conversion of methane and other alkanes to their corresponding oxygenated products. 

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