Respiratory infections specific agents

Respiratory Effects. Although no respiratory effects have been reported in humans following dermal exposure exclusively to 3,3 -dichlorobenzidine, upper respiratory infection and sore throat were among the principal reasons for visits to a company s medical clinic by workers who handled 3,3 -dichlorobenzidine (Gerarde and Gerarde 1974). However, there is no conclusive evidence that these effects were due specifically to 3,3 -dichlorobenzidine exposure. Workers may have been exposed to this and/or other agents by both inhalation and dermal routes. 

Clarithromycin is an H. pylori agent/macrolide, which inhibits microbial protein synthesis. Clarithromycin is indicated in the treatment of infections of the respiratory tract, skin and skin structure treatment of disseminated atypical mycobacterial infections caused by susceptible strains of specific microorganisms and prevention of disseminated Mycobacterium avium complex disease in patients with advanced HIV infection. Clarithromycin in combination with omeprazole is indicated in the treatment of patients with an active duodenal ulcer associated with H. pylori infection. In children it is used in acute otitis media. Macrolides are erythromycin, clarithromycin, and azithromycin. 

The hallmark of an inflammatory response in the lung is the presence of infiltrating leukocytes. This process can occur in the context of a variety of disorders, including trauma, infection, autoimmune diseases, idiopathic interstitial pneumonias, asthma, chronic bronchitis, acute respiratory distress syndrome (ARDS), exposure to environmental/occupational noxious agents, cancer, aUograft rejection, and ischemia-reperfusion injury. The course of inflammation in these disease states is defined by the delicate balance and nature of inflammatory mediators expressed in the context of lung inflammation, and the specific leukocyte populations recmited in response to lung injury. 

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