Reliability scores

We found four types of timing skills in the literature time estimation, time production, time comparison and time reproduction. The last appealed to us most, since it seemed to lend itself to automated administration and scoring. For example, subjects could easily produce, and reproduce with appropriate correction, an interval of 5 seconds. The average of 25 responses produced reliable scores, using error zones as shown in Figure 2. 

Cell-based analysis (19,25) is related to cell-based design (see Subheading 2.3.). When the compounds in the initial set are assayed, the cells in the various subspaces are scored according to the proportion of active compounds. A new and not assayed compound can then be rated by combining the scores of the cells to which it belongs. Cells for analysis are typically made a little larger than those used for design, so that each cell has about 10 assayed compounds and the proportion that are active is a reasonably reliable measure. This leads to reliable scores for new compounds. 

The main advantage of SVM over other data analysis methods is its relatively low sensitivity to data overfitting, even with the use of a large number of redundant and overlapping molecular descriptors. This is due to its reliance on the structural risk minimization principle. Another advantage of SVM is the ability to calculate a reliability score, R-value, which provides a measure of the probability of a correct classification of a compound [70], The R-value is computed by using the distance between the position of the compound and the hyperplane in the hyperspace. The expected classification accuracy for the compound can then be obtained from the 7 -value by using a chart which shows the statistical relationship between them. As with other methods, SVM requires a sufficient number of samples to develop a classification system and irrelevant molecular descriptors may reduce the prediction accuracies of the SVM classification systems. 

Molecular docking tools are still far away from giving reliable results for all kinds of protein-ligand complexes. The complexity of the problem increases with the number of rotatable bonds in the ligand and the flexibility of the active site. In addition there is the lack of a reliable scoring function for the prediction of the free energy of binding. 

For most of these topics, it is too early to judge whether they will mature into reliable scoring techniques vith significant impact on structure-based virtual screening. However, significant improvements in these fields are expected. 

For both translations, confirmatory factor analysis showed an acceptable fit with the original 12-dimensional model. Although exploratory factor analysis resulted in a 10-dimensional and a 9-dimensional stracture for, respectively, the Dutch and French questionnaires, based on the acceptable validity and reliability scores, it was concluded that no modifications were required to the original 12-factor model in order to allow internal and external benchmarking for the psychiatric hospitals. 

Becanse audits are typically designed by safety professionals, they would be assumed to have content-based validity. Certainly the questions are those deemed by the designers to be the most important indicators of safety performance. The fact that, at least in some circumstances, reliable scores can be generated should satisfy us that the method has content-based validity. The presence of reliability indicates that several auditors are using similar definitions of the content, which provides a validation of that content. 

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