Recombinant serotype

Du, L. L., Kido, M., Lee, D. V. et al. (2004). Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol. Ther. 10(3), 604-608. 

Gao G, Vandenberghe LH, Wilson JM. New recombinant serotypes of AAV vectors. Curr Gene Ther 2005 5 285-297. 

Engerix B (tradename) is a subunit vaccine containing purified recombinant hepatitis B surface antigen (HBsAg) that gained approval in the USA in 1998. It is indicated for active immunization against infection caused by all known serotypes of hepatitis B virus. 

P.J. Reier, R.J. Mandel, and N. Muzyczka. 2004. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential effi-... 

The active 2A and 3C proteases from different HRV serotypes have been overproduced in bacterial cells and purified by several groups [18,28-42], The availability of large quantities of the recombinant viral proteases has greatly facilitated their biochemical characterization, assay development, and efforts to identify specific inhibitors against these enzymes. We have worked on the purification and assay development for the two proteases from HRV serotype-14 (HRV 14) as part of our efforts in antiviral development. The experimental procedures described below may provide a general approach toward the purification and development of high-throughput assays for the 2A and 3C proteases of other HRV serotypes as well as other members of the picomaviral family. 

Zolotukhin, S. et al. (2002). Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods 28, 158-167. 

Recombinant AAV serotype 2 vectors were developed for CFTR gene transfer. These vectors were designed to overcome the intrinsic packaging limitation of rAAV by fitting the relatively large coding sequence of CFTR (approximately 4.5 kb), with minimal promoter... 

Flotte, T. R., Zeitlin, P. L., Reynolds, T. C., Heald, A. E., Pedersen, P., Beck, S., Conrad, C. K., Brass-Ernst, L., Humphries, M., Sullivan, K., Wetzel, R., Taylor, G., Carter, B. J. and Guggino, W. B. (2003). Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients A two-part clinical study. Hum. Gene. Ther. 14, 1079-1088. 

Mastakov, M. Y. et al. (2002). Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain Quantitative analysis of heparin co-infusion. Mol. Ther. 5(4), 371-380. 

Wang, C. et al. (2003). Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain. Gene Ther. 10(17), 1528-1534. 

Weber, M. et al. (2003). Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery. Mol. Ther. 7(6), 774-781. 

Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J. and Muzyczka, N. (2004). Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol. Ther. 10, 302-317. 

Sugiyama, T., Kido, N., Kato, Y., Koide, N., Yoshida, T., Yokochi, T. Generation of Escherichia coli 09a serotype, a subtype of E. coli 09, by transfer of the wb gene cluster of Klebsiella 03 into E. coli via recombination. J Bacteriol 180 (1998) 2775-2778. 

Pacak CA, Mah CS, Thattaliyath BD, Conlon TJ, Lewis MA, Qoutier DE, Zolotukhin I, Tarantal AE, Byrne BJ. Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res 2006 99 e3-e9. 

Grimm D, Pandey K, Nakai H, Storm TA, Kay MA. Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol 2006,80 426 39. 

Boles, J., West, M., Montgomery, V., Tammariello, R., Pitt, M.L., Gibbs, P., Smith, L., and LeClair, R.D. 2006. Recombinant C fragment of botulinum neurotoxin B serotype (rBoNTB) (HC) immune response and protection in the rhesus monkey. Toxicon 47 877-884. 

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