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Nigrostriatal lesions MPTP

However, MPPP is sometimes contaminated with the side reaction product l-methyl,4-phenyl-l,2,3,6-tetra-hydropyridine (MPTP), which produces a parkinsonian syndrome through nigrostriatal lesions. Several substituted derivatives of amphetamine have also been called designer drugs. The most widely known of this group is the hallucinogen MDMA (ecstasy). [Pg.419]

Dopaminergic neurotoxin that causes parkinsonism via lesion of nigrostriatal dopamine neurons in rat, mice, monkeys. Unlike the dopaminergic neurotoxin MPTP (N-methy 1-4-phenyl-1,2,3,6-tetrahydropyridine) it does not cross the blood-brain barrier. [Pg.605]

Chadi, G., Moller, A., Rosen, L., Janson, A. M., Agnati, L. A., Goldstein, M., Ogren, S. O., Pettersson, R. F., and Fuxe, K., Protective actions of human fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion, lixp. Brain Res., 97, 145, 1993. [Pg.212]

Schober A, Peterziel H, Von Bartheld CS et al (2007) GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action. Neurobiol Dis 25 378-391... [Pg.122]

See other pages where Nigrostriatal lesions MPTP is mentioned: [Pg.268]    [Pg.270]    [Pg.534]    [Pg.254]    [Pg.268]    [Pg.369]    [Pg.369]    [Pg.529]    [Pg.202]    [Pg.497]    [Pg.453]    [Pg.63]    [Pg.462]    [Pg.358]    [Pg.4714]    [Pg.4715]   
See also in sourсe #XX -- [ Pg.3 , Pg.56 , Pg.70 , Pg.77 , Pg.133 , Pg.134 , Pg.156 , Pg.159 , Pg.171 , Pg.172 , Pg.173 , Pg.174 , Pg.175 , Pg.176 , Pg.177 , Pg.178 , Pg.179 , Pg.180 , Pg.181 , Pg.182 , Pg.225 , Pg.226 , Pg.237 , Pg.313 , Pg.314 , Pg.330 , Pg.410 , Pg.412 ]



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Lesion

MPTP

Nigrostriatal lesions

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