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Recombinant human BMP

Matsuo T, Sugita T, Kubo T. Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. J Biomed Mater Res A 2003 66A 747-54. [Pg.157]

Hong L, Tabata Y, Yamamoto M, Miyamoto S, Yamada K, Hashimoto N, et al. Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution. J Biomater Sci Polym Ed 1998 9(9) 1001. [Pg.292]

M. Murata, F. Maki, D. Sato, T. Shibata, and M. Arisue, Bone Augmentation by Onlay Implant using Recombinant Human BMP-2 and Collagen on Adult Rat Skull without Periosteum, Clin. Oral Implants Res., 11,289-295,2000. [Pg.472]

Human BMP is therapeutically active in milligram doses but is present in cortical bone in the concentration of only 1-2 /xg/kg, making it impractical to extract sufficient quantities for clinical use. Therefore, therapeutic quantities are produced commercially through molecular biology techniques (recombinant BMP - rhBMP). Two are currently available for clinical use rhBMP-2 (Infuse Medtronic Sofamor Danek, Memphis, Tennessee) and rhBMP-7 (OP-1 Stryker, Kalamazoo, Michigan). [Pg.209]

Chen, P. et al. Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor beta 1 and beta 2, Exp. Cell Res., 195,509,1991. [Pg.495]

A number of delivery systems have been developed for the controlled release of bone morphogenic protein-2 (BMP-2). For example, calcimn phosphate cement-based materials have shown the ability to deliver recombinant human bone morphogenic protein-2 (rhBMP-2) to increase alkaline phosphatase (ALP) activity in MC3T3-E1 cells in vitro,and enhance bone formation both ectopically and in an ulna osteotomy model. In addition to cement-based systems, polymeric materials have also been heavily researched as potential delivery vehicles of BMP-2. Saito et al. have developed a temperature sensitive poly(D,L-lactic acid-polyethylene glycol) (PLA-PEG) block copolymer as an... [Pg.436]

Recombinant proteins TPA, protein A, hemoglobin, BMP, human growhi hormone, IL2, and antibodies Vaccines Influenza, hepatitis, DPT, cholera, and... [Pg.412]

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