Recognition of carbohydrates

Volume 362. Recognition of Carbohydrates in Biological Systems (Part A) Edited by Yuan C. Lee and Reiko T. Lee... 

VI. The Conformations and Molecular Recognition of Carbohydrate Determinants Distant from the Protein Oligosaccharide Core of Glycoproteins... 

Several of the aforementioned methods, and others, have been applied to the recognition of carbohydrates. The most widely used of them will be further discussed, distinguishing whether they were applied to monolayers (2D-arrays) or to vesicles (3D-systems). 

Template-metal coordinative bonds have also been used in the imprinting and recognition of carbohydrates in aqueous media. A MIP, templated with glucose and using 4-(iV-vinylbenzyl)diethylenetriamine)Cu(H)]diformate as... 

This volume contains the papers presented in a symposium on carbohydrate-protein interaction. The symposium was devoted to an exploration of protein-glycoconjugate interaction in a wide range of biological phenomena the interaction of enzymes, antibodies, and lectins with complementary carbohydrate molecules the recognition of carbohydrate-containing structures by chemoreceptors such as taste and other plasma membrane proteins and the role of carbohydrates in the organization of connective tissue. 

M. Wendeler, H. Reiiaender, J. Hoernschemeyer, G. Schwarzmann, T. Kolter, K. Sandhoff, Recombinant Ganglioside GM2-Synthase - Expression in Insect Cells and Enzyme Assay, Y. C. Lee, R. T. Lee, eds., Methods in Enzymology Recognition of Carbohydrates in Biological Systems, submitted for publication. 

Fig. 2.1.1. Achiral artificial receptors for the recognition of carbohydrates via hydrogen bonds [1, 3h].

Much work still needs to be done to develop artificial receptors that combine sufficient orientation through an array of hydrogen bond contacts with favorable hydrophobic effects to provide sufficient binding energy to reach the ultimate goal - effective and biomimetic recognition of carbohydrates in water. 

Nature has developed a huge diversity of independent protein architectures for recognition of carbohydrates but, despite this broad variety, in accordance with the numerous events involving carbohydrate binding processes, these structures do share some common key features. Irrespective of... 

Figure 5.38 Scheme of the stereoselective recognition of carbohydrates by helical cholesteric phases containing boron esters. 

PHOSPHORESCENCE PROPERTIES OF 2-BROMOQUINOLINE-3-BORONIC ACID IN SODIUM DEOXYCHOLATE AND ITS POTENTIAL APPLICATION IN RECOGNITION OF CARBOHYDRATES... 

Recognition of carbohydrates based on binding induced RTP enhancement. 

One important area of current research is on the recognition of carbohydrates. In particular, cell surface carbohydrates have implications in various disease states. In some forms of cancer, closely packed cell surface carbohydrates effect cancer progression and invasiveness. Many of these carbohydrates have terminal sialic acid groups. The pinwheel receptor 42 was designed as a divalent receptor for anionic sugars including sialic acid with a view toward making sensors for cancer markers. Sensor 42 used a boronic acid to bind a diol on the... 

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