Recognition effectors

A mechanism of cell-mediated immunity whereby an effector cell of the immune system actively lyses a target cell that has been bound by specific antibodies. The typical ADCC involves activation of natural killer (NR) cells and is dependent on the recognition of... 

Ubiquitin modification of substrates can be sensed by proteins, which serve as ubiquitin receptors. These proteins harbor domains capable of ubiquitin binding and help to translate the signal into the proper physiological response by forming signaling complexes or activating downstream effectors. So far more than 15 different ubiquitin recognition motifs have been identified. 

Natural killer (NK) cells are bone marrow-derived large granular lymphocytes playing an important role in the innate immunity, especially against viruses and tumor cells, and they form 10-15% of the total lymphocyte population. NK cells have the ability to lyse cells without specific antigen recognition, and these cells may be considered as effector cells, especially in the innate... 

Life depends on molecnlar recognition specific base-pairing in nncleic acids recognition of snbstrates by enzymes of effectors by receptors of antigens by antibodies. 

Figure 8.3. Schematic representation of bispecific antobody mediated tumor cell recognition by an immune effector cell. Summarised are effector cell types, trigger molecules and tumor associated antigens used as a targed as reported in the literature. From reference [37].

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