Receptors and Signals

MacGlashan D Jr IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol 2008 20 717-723. 

Brink CB, Harvey BH, Bodenstein J, Venter DP, Oliver DW. Recent advances in drug action and therapeutics relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology. Br J Clin Pharmacol 2004 57(4) 373-387. 

Drug-receptor interactions Dose-response relationships Molecular modeLs of receptors and signal transduction mechanisms Biotr an s fo r m ati on Ph ar macokine t ios Ph armacody namics... 

Powers, C.J., McLeskey, S.W., and Wellstein, A. 2000. Fibroblast growth factors, their receptors and signalling. Endocrine Related Cancer 1(3), 165-197. 

Zahniser, N. R. and Doolen, S. Chronic and acute regulation of Na+/Cl"-dependent neurotransmitter transporters drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol. Ther. 92 21-55, 2001. 

Rubinstein, M. et al., Recent advances in cytokines, cytokine receptors and signal transduction, Cytokine Growth Factor Rev., 9, 175, 1998. 

Phagocytosis and encapsulation, in which pathogens are sequestered within several layers of cells, are the predominant cellular immune responses. Genetic and molecular studies have shown that bacterial products are recognized24 and transduced by host cells25 26 by similar pattern recognition receptors and signal transduction pathways in both vertebrates and invertebrates. 

Powers, C. et. al. (2000). Fibroblast growth factors, their receptors and signalling. Endocr. Rel. Cancer 7(3), 165-197. Souchelnytskyi, S. (2002). Transforming growth factor-/) signalling and its role in cancer. Exp. Oncol. 24(1), 3-12. Zhu, X., Komiya, A., Chirino, S. et al. (1991). Three-dimensional structures of acidic and basic fibroblast growth factors. Science 251, 90. 

Variability of the Receptor and Signal Response in the Target Cell... 

The highly variable nature of signaling pathways is also expressed by the fact that different receptors and signaling pathways can induce the same biochemical reaction in a cell. This is exemplified by the release of Ca, which can be regulated via different signaling pathways (see chapters 5-7). 

The cell has other transmembrane receptors and signaling pathways that do not fit into the. .classical" receptor types and signal mechanisms described in Chapters 5-11. The following signaling pathways certainly do not complete the list of intercellular and intracellular commimication mechanisms in mammals, and it is to be expected that other classes of signaling pathways will be described in the future. 

Smith DM et al Adrenomedullin Receptor and signal transduction. Biochem Soc Trans 2002 30 432. [PMID 12196109]... 

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