Adrenomedullin receptor

Smith DM et al Adrenomedullin Receptor and signal transduction. Biochem Soc Trans 2002 30 432. [PMID 12196109]... 

In animals, adrenomedullin dilates resistance vessels in the kidney, brain, lung, hind limbs, and mesentery, resulting in a marked, long-lasting hypotension. The hypotension in turn causes reflex increases in heart rate and cardiac output. Adrenomedullin also acts on the kidneys to increase sodium excretion, and exerts several endocrine effects including inhibition of aldosterone and insulin secretion. Finally it acts on the central nervous system to increase sympathetic outflow. These diverse actions of adrenomedullin are mediated both by CGRP receptors and unique adrenomedullin receptors, the properties of which are incompletely defined. The major second messenger for both receptors is cAMP. 

Hay DL, Conner AC, Howitt SG, Smith DM, Poyner DR. The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors. J Mol Neurosci 2004 22 105-113. 

Hay, D.L. and Smith, D.M., Adrenomedullin receptors molecular identity and function. Peptides 22, 1753-1763, 2001 Julian, M., Cacho, M., Garcia, M.A. et al., Adrenomedullin a new target for the design of small molecule modulators with promising pharmacological activities, Eur. J. Med. Chem. 40,737-750,2005 Shimosawa, T. and Fujita, T., AdrenomeduUin and its related peptides, Endocr. J. 52,1-10, 2005 Zudaire, E., Portal-Nunez, S., and Cuttitta, F., The central role of adrenomedullin in host defense, J. Leak. Biol. 80, 237-244, 2006 Hamid, S.A. and Baxter, G.F, A critical cytoprotec-tive role of endogenous adrenomedullin in acute myocardial infarction, J. Mol. Cell Cardiol. 41, 360-363, 2006. 

Koller, D. et al. (2004) Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor. J. Biol. Chem. 279, 20387-20391. 

Poyner DR et al International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002 54 233. [PMID 12037140]... 

Hasback, P., Sams, A., Schifter, S., Longmore, J., Edvinsson, L. CGRP receptor mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with CompoundV (W09811128), a non-peptide antagonist, Br. J. Pharmacol. 2001, 133, 1405-1413. 

Fernandez-Sauze S, Delfino C, Mabrouk K, Dussert C, Chinot O, Martin PM, et al. Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis Involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors. Int J Cancer 2004 108 797-804. 

Alexander. S.P.H. er al. (1998) Receptors and ion channel nomenclature supplement Ninth Edition. Trends Pharmacol. ScL, Supfd., 19.1-98. Nishikimi.T. (1998) Adrenomedullin in cardiovascular disease. Adv. Pharmact., 42.599-603. 

Cooper, G.J.S. (1994) Amylin compared with calcitonin gene-related peptide Structure, biology, and relevance to metabolic disease. Endocr. Rev.. 1. 163 201. Wimalawansa, S.J. (1997) Amylin. calcitonin gene-related peptide, calcitonin, and adrenomedullin a peptide superfamlly. Cr/r. Rev. Neurobiol., 11.167-239. Alexander. S.P.H. et al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Sc/.. Suppl.. 19.1-98. 

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