Transmembrane tyrosine kinase receptor

Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P., and Bernstein, A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335 88-89. 

GDI 17 c-kit) is a transmembrane tyrosine kinase receptor that has been immunolocalized in various neoplasms, the most notable of which is gastrointestinal stromal tumors where c-kit is felt to be a relatively specihc and sensitive immunohistochemical marker of gastrointestinal stromal tumors. If a gastrointestinal stromal tumor expresses CD 117, it is usually treated with Gleevec. GDI 17 has been evaluated in lung and pleural neoplasms. 

The insulin receptor is a transmembrane receptor belonging to the tyrosine kinase receptor class (Figure 13.6). Two a and two /S subunits make up the insulin receptor. The p subunits pass through the cell membrane and are linked by disulphide bonds. The a and p subunits are encoded by a single gene (INSR). 

SCF is a ligand that is expressed on Sertoli cells. A proteolytic cleavage site within exon 6 results in two isoforms of SCF, a soluble isoform (sSCF) and a membrane-bound isoform (mSCF). c-Kit, the SCF receptor, is a 145-kD transmembrane tyrosine kinase expressed on germ cells and Leydig cells, the... 

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