PROPHET system

The PROPHET system is sponsored by the Biotechnology Resources Program, Division of Research Resources, National Institutes of Health under contract N01-RR-8-2118. 

D. C. Rohrer, D. S. Fullerton, K. Yoshioka, A. H. L. Frome, K. Ahmed (1979). Functional receptor mapping for modified cardenolides use of the Prophet system. In E. C. Olson, R. E. Christoffersen (Eds.). Computer Assisted Drug Design. Washington, DC American Chemical Society, pp. 259-279. 

This work was supported by the National Institute on Drug Abuse (DA 91875). The computations were supported in part by a grant of computer time from the University Computer Center of the City University of New York. Analysis of results in this work was carried out in part on the PROPHET System, a national computer resource sponsored by the NIH through the Chemical/Biological Information - Handling Program, Division of Research. H.W. in recipient of a Career Scientist Award from the Irma T. Hirschl Trust. 

Functional Receptor Mapping for Modified Cardenolides Use of the PROPHET System... 

Chemical Abstracts and GAS Registry. CAS is especially notable for the thoroughness and high quaUty of its products. The CAS Registry system does a superb job of identifying any chemical that is either involved in new chemistry with hard data, or, since about 1980, specifically claimed in a patent. The MARPAT database has also led CAS to identify the perhaps nonexistent but prophetic substances covered by Markush claims in patents. 

Based on their corporate experience in supporting their own research and development projects as well as a number of government-sponsored activities, the development of scientific software at BBN grew out of a long history of support of a variety of scientific applications. For example, in the 1960 s, BBN developed a hospital information system for Massachusetts General Hospital which used an early minicomputer, the PDP-1, to support clinical research activities. Under the sponsorship of the National Institutes of Health, they developed a system called PROPHET (1) which provides a... 

The first method has little to recommend it, because of the difficulty of purifying chlorine. The second method was favoured by Fairbrother, Scott and Prophet (1956) for their studies on the solubility of AICI3 in various hydrocarbons. Dry HCl was passed over A1 wire kept at 400-500 °C, the product was sublimed four times in a high vacuum system and sealed into a series of break-seal ampoules. Although it is not stated explicitly, this procedure involves the (slight) difficulty of doing the actual synthesis more or less at atmospheric pressure, and then changing to vacuum operation. 

These studies were aided by grants from the National Science Foundation, BMS-72-02219 A04 and PCM76-81029. Work with the PROPHET computer system is sponsored by the National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of General Medical Sciences, Division of Research Resources (Contract No. NOl-RR-42147), National Institutes of Health. 

Fig. 6. Variability at different positions for the variable region of heavy chains. The plot was made by the PROPHET Computer System (Raub, 1974). From Kabat et al. (1976b).

Thermodynamic Research Center (TRC), Thermodynamic Tables of Hydrocarbons, formerly American Petroleum Institute Project 44 (see Ref [8]) (published as loose leaf sheets by Texas A M University, College Station, TX presently NIST-TRC Boulder Co.), (a) D. R. Stull and H. Prophet, JANAF Thermo chemical Tables, 2nd edition, NSRDS-NBS 37, National Standard Reference Data System (NSRDS), National Bureau of Standards (NBS), Washington, DC (1971). (b) M. W. Chase, Jr., C. A. Davies, J. R. Downey, Jr., D. J. Fmrip, R. A. McDonald, and A. N. Syvemd, JANAF Thermo chemical Tables, 3rd edition (Parts I and II), J. Phys. Chem. Ref, Data 14 (Suppl. 1), 1-1856 (1985). (c) M. W. Chase,... 

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