Receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

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Engelman HS, Anderson RL, Daniele C, MacDermott AB (2006) Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience 139 539 Engelman HS, MacDermott AB (2004) Presynaptic ionotropic receptors and control of transmitter release. Nat Rev Neurosci 5 135 45... 

Pasternack, A., Coleman, S. K.,Jouppila, A., Mottershead, D. G., Lindfors, M., Pasternack, M., and Keinanen, K. (2002). Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain. J. Biol. Chem. 277, 49662-49667. 

Xu G, Ong J, Liu YZ, Silverstein FS, Barks JD (2005) Subventricular zone proliferation after alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated neonatal brain injury. Dev Neurosci 27 228-234. 

Arai A, Kessler M, Rogers G et al (1996) Effects of a memory-enhancing drug on DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents and synaptic transmission in hippocampus. J Pharmacol Exp Ther 278 627-638... 

Menniti FS, Chenard BL, Collins MB et al (2000) Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists. Mol Pharmacol 58 1310-1317... 

Abbreviations AON, anterior olfactory nucleus mAChR, muscarinic cholinergic receptor nAChR, nicotinic cholinergic receptor alpha and beta adrenergic receptors NMDA, N-methyl-D-Aspartate receptor AMPA, a-amino-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GABAa/b, gamma aminobutyric acidreceptor. 

Most often more than one neurotransmitter is released at the same time. Aspartate and glutamate are excitatory amino-acids (EAAs) involved in pain transmission [4,5]. Glutamate is the main excitatory CNS nem-otransmitter and mediates rapid, short-duration depolarization of second-order neurons. Peptides such as substance P and neurokinin are responsible for delayed long-lasting depolarization. EAAs act on various receptors, which principally include alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic... 

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