4-amino-3-hydroxy-2-methyl

Transient intermediates arising by radical additions to the amide bond have been studied recently in an effort to explain the complex processes occurring in electron-capture dissociation of multiply charged peptide and protein cations [192]. The amino(hydroxy)methyl radical, HC(OH)NH2 (64), is a prototypical species that represents the simplest model for radical additions to peptide bonds. Radical 64 was generated from cation 64+ which in turn was prepared by... 

Pigment Red 52, calcium salt [17852-99-2] 15860 BONA (Ca salt) coupling of dia2oti2ed 2-amino-4-methyl-5-chloroben2enesulfonic acid with 3-hydroxy-2-naphthoic acid, foUowed by salt formation... 

Table 11 summarizes the main results on the tautomerism of mono-hydroxy-, -mercapto-, -amino- and -methyl-azines and their benzo derivatives, in water. At first sight the equilibrium between 2-hydroxypyridine (71) and pyridin-2-one (72) is one between a benzenoid and a non-benzenoid molecule respectively (71a 72a). However, the pyridinone evidently... 

Coumarin, 7-amino-7-(diethylamino)-, I, 333 Coumarin, 7-amino-4-methyl-fluorescence spectra, 3, 601 Coumarin, 7-amino-3-phenyl-brightening agents, I, 339 Coumarin, 4-aryl-occurrence, 3, 677 synthesis, 3, 810 Coumarin, 3-arylazo-4-hydroxy-structure, 3, 643 Coumarin, 3-bromo-reactions... 

Quinoline, amino-2-hydroxy-4-methyl-azo pigments from, 1, 334 Quinoline, 8-amino-6-methoxy-as antimalarial, 2, 517 Quinoline, 4-amino-2-methyl-protonation, 2, 341 Quinoline, anilino-3-substituted... 

Quinolizinium salts, 2-amino-l-hydroxy-diazotization, 2, 542 Quinolizinium salts, l-amino-3-methyl-diazotization, 2, 542 Quinolizinium salts, 2-bromo-synthesis, 2, 544 Quinolizinium salts, carboxy-anhydrides... 

Thiazole, 5-amino-4-ethoxycarbonyl-2-methyl-synthesis, 6, 306 Thiazole, 2-amino-4-(2 -furyl)-bromination, 6, 256 Thiazole, 2-amino-4-hydroxy-synthesis, 6, 296 Thiazole, 5-amino-2-hydroxy-synthesis, 6, 301 Thiazole, 5-amino-2-mercapto-synthesis, 6, 301 Thiazole, 2-amino-4-methyl-alkylation, 6, 256 synthesis, 6, 300 Thiazole, 2-amino-5-nitro-antiparasitic activity, 1, 180... 

Step G 4-fOrtho-(2, 3 -Dihydroxypropyloxycarbonyl)-Phenyl]-Amino-8-Trifluoromethyl-quinoHne Acetonide — 100 cc of toluene were added to 80 cc of 2,2-dimethyl-4-hydroxy-methyl-1,3-dioxolane and the toluene was distilled off under reduced pressure to eliminate the water present. To the anhydrous 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane thus obtained, 0.25 gram of an oily 50% suspension of sodium hydride and then 21.3 grams of 4-... 

Chemical Name N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl] -N -[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio] -1 -butenyi] formamide... 

Carbethoxy-4-hydrOxy-2-methyl-2H-1 -benzothiazine-1,1-dioxide 3-Amino-5-methyl-isoxazole... 

In chlorinations either a substitution or an addition process can occur with the ultimate reaction pathway(s) determined by a combination of factors, which include the reaction conditions, the positions and natures of any substituents present, and the catalyst used. Uncatalyzed chlorination of benzothiadiazole is an exothermic reaction that gives rise to a mixture of isomeric tetrachloro addition products. These are converted in basic medium into 4,7-dichloro-2,1,3-benzothiadiazole (70RCR923). When an iron(III) catalyst is present 4- and 7-chloro substitution becomes the dominant process. Chlorination of a number of 4-substituted 2,1,3-benzothiadiazoles (43) using an oxidative process gave a combination of chlorinated and oxidized products. The 4-hydroxy, 4-amino-, 4-methyl-amino, and 4-acetoxy derivatives of 43 all formed the chloroquinones (44) (40-61% yields). With the 4-aIkoxy substrates both 44 and some 5,7-dichlorinated product were obtained (88CHE96). 

Balli and Felder (1978) and Balli and Ritter (1981) showed that diazo transfer can be applied advantageously to the diazotization of sufficiently nucleophilic heteroaromatic compounds such as 5-hydroxy- and 5-amino-3-methyl-l-phenyl-pyrazole if 3-ethyl-2-azido-benzthiazolium tetrafluoroborate (2.50) is used as diazo transfer reagent (for other applications of this diazo transfer reagent see Zollinger, 1995, Secs. 2.6-2.8). The diazonio group is introduced in the 4-position (2.51). 

Octadecanol — (Jndecen-(lO)-ol — J, 2-Bis-[hydroxy-methyl]-benz.oI — 4-Amino-l-melhyI-benzol... 

Hydroxy-butyl)-l-( -hydroxy-benzyl)- 296 Hydroxylamino- 474, 682 4-Hydroxylamino-l-athylthio- 684 Hydroxylamino-alk(aryl)oxy- 684 2-Hydroxylamino-1 -isopropenyl- 698 4-Hydroxyl amino-1 -methyl- 683 4-Hydroxylamino-1 -methylthio- 684 2-Hydroxylamino-l-nitro- 562 2-Hydroxylamino-l-[penten-(l)-yl-(2)J- 698 4-Hydroxylamino-l-phenylthio- 684 4-Hydroxylamino-1 -sulfonyl- 683 Hydroxymethyl- 499... 

CN yV-l(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-l-methyl-2-[[(tetrahydro-2-furanyl)methyl]dilhio]-l-butenyl]formamide... 

CN [OC-6-24-(25 -frani)]-[/V-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-/V-(4-hydroxy-2-mercapto-l-... 

The photocycloaddition of aliphatic and aromatic aldehydes with 2,4,5-trimethyloxazole (131) gave bicyclic oxetanes 132 in almost quantitative yields hydrolitic cleavage led selectively to erytro a-amino-P-hydroxy methyl ketones 133 <00CC589>. The oxazolium salt 134 was converted to the azomethine ylide 136 via electrocyclic ring opening of the oxazoline 135. Intramolecular cycloaddition afforded 137 in 66% overall yield which was transformed into the aziridinomitosene derivative 138 . 

The formation of oxygen-containing heterocyclic compounds is also a consequence of the Maillard reaction. Amines and amino acids have a catalytic effect upon the formation of 2-furaldehyde (5), 5-(hydroxy-methyl)-2-furaldehyde (11),2-(2-hydroxyacetyl)furan (44),2 and 4-hy-droxy-5-methyl-3(2//)-furanone (111) (see Ref. 214). This catalytic effect can be observed with several other non-nitrogenous products, including maltol. The amino acid or amine catalysis has been attributed to the transient formation of enamines or immonium ions, or the 1,2-2,3 eno-lization of carbohydrates. Of interest is the detection of A -(2-furoyl-... 

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