Reagins

Shields MS, MJ Reagin, RR Gerger, R Campbell, C Somerville (1995) TOM, a new aromatic degradative plasmid from Burkholderia (Pseudomonas) cepacia G4. Appl Environ Microbiol 61 1352-1356. 

Munakata-Marr J, PL McCarty, MS Shields, M Reagin, CS Francesconi (1996) Enhancement of trichloroethylene degradation in aquifer microcosms bioaugmented with wild-type and genetically altered Burk-holderia Pseudomonas cepacia G4 and PRl. Environ Sci Technol 30 2045-2052. 

Syphilis. Early disease may be characterized by a single genital lesion. Diagnosed by positive serologic testing [e.g., VDRL or rapid plasma reagin (RPR) test]. 

Diagnostic procedures include dark-field microscopy12, non-treponemal exams10 (i.e., the Venereal Disease Laboratory and the rapid plasma reagin test), and treponemal exams (i.e., enzyme immunoassay, the T. pallidum hemagglutination test, the fluorescent treponemal antibody test, and the enzyme-linked immunosorbent assay). 

Serologic tests are the mainstay in the diagnosis of syphilis and are categorized as nontreponemal or treponemal. Commonly used nontrep-onemal tests include the Venereal Disease Research Laboratory shde test, the rapid plasma reagin card test, the unheated serum regain test, and the toluidine red unheated serum test. 

IgE <0.0001 Reaginic antibody involved in immediate hypersensitivity antihelminthic does not bind complement... 

I, Immediate (reaginic) Food additives (Gl allergies anaphylactic) Penicillin uticaria and dermatitis Mast cells IgE Anaphylaxis, asthma, urticaria, rhinitis, dermatitis IgE binds to mast cells to stimulate release of humoral factors... 

Lee WY, Sehon AH Abrogation of reaginic antibodies with modified proteins. Nature 1977 267 618-620. 

The reported potentiation by ozone of the membrane damage produced by the indirect pathway of complement d might also play a role if it occurs in vivo, inasmuch as this complement pathway apparent mediates the allergin-reagin-induced release of histamine. in view of... 

Mall, A., L. Baecher, G. Crossley, and D. Burger. Allergen-reagin-mediated histamine release reactions. Int. Arch. Allergy Appl. Immunol. 44 122-139, 1973. 

Late antibodies Mucosa-protecting antibodies Early antibodies B-lymphocyte receptors Reagins... 

Treponemal antibodies and reagins are true immunoglobulins consisting mainly of IgM, but also of IgG. IgM appears early in the infection. 

Shields, M. S. Reagin,M. J. (1992). Se[ecuono(a Pseudomonas cepacia strain constitutive for the degradation of trichloroethylene. Applied and Environmental Microbiology, 58,3977-83. 

A protein which possesses reaginic activity but does not appear to belong to the other classes of immunoglobulin is transmitted to suckled calves through colostrum (Hammer et al. 1971 Benton et al. 1976). It has been tentatively accepted as IgE, since it cross-reacts with human IgE (Nielson 1977). In molecular size it lies between IgG and IgM (Hammer et al 1971 Wells and Eyre, 1971). This immunoglobulin needs to be further investigated and characterized. 

Nielson, K. H. 1977. Bovine reaginic antibody. III. Cross reaction of anti-human IgE and antibovine reaginic immunoglobulin antisera with sera from several species of mammals. Can. J. Comp. Med. 41, 345-348. 

Ishizaka K, Ishizaka T. 1967. Identification of gamma-E-antibodies as carrier of reaginic activity. J Immunol. 99 1187-1198. 

Nielsen, B.R., Poulsen, O.M., and Hau, J. 1989. Reagin production in mice Effect of subcutaneous and oral sensitization with untreated bovine milk and homogenized bovine milk. In Vivo 3(4) 271-274. 

Anaphylactic Reactions Free antigen Reaginic antibody (IgE) fixed to Degranulation of cell and release... 

ACE = angiotensin-converting enzyme ANA = antinuclear antibody ANCA = antineutrophil cytoplasmic antibody BUN = blood urea nitrogen CBC = complete blood count ELISA = enzyme-Mnked immunoassay assay ESR = erythrocyte sedimentation rate FTA-ABS = fluorescent treponemal antibody absorption HLA = human lymphocyte antigen MHA-TP = micro-hemagglutination-7re/ OMew pallidum-, PPD = purified protein derivative RPR = rapid plasma reagin VDRL = venereal disease reference laboratory. 

Venereal Disease Research Laboratory or rapid plasma reagin... 

An atopic person has reaginic antibodies directed against common environmental allergens, and since immunoglobulin E (IgE) is the most important reaginic antibody in man its measurement is relevant to both clinical allergists and immunologists. 

Cromoglicate inhibits mast-ceU degranulation and histamine release induced by phosphohpase A2, but does not interfere with the interaction of antigen and reaginic antibodies. Evidence is accumulating that it has an important stabilizing action on leukocytes, apart from mast cells, such as neutrophils, eosinophils, and monocytes, and that it also affects nerve reflexes in the lung (2). 

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