Reactive oxygen species formation

Lovric J, Cho SJ, Winnik FM, Maysinger D (2005) Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem Biol 12 1227-1234... 

Xiao XQ, Zhang HY, Tang XC, Huperzine A attenuates amyloid fl-peptide fragment 25-35-induced apoptosis in rat cortical neutons via inhibiting reactive oxygen species formation and caspase-3 activation, J Neurosci Res 67 30—36, 2002. 

Menon, E. L., Perera, R., Kuhn, R. J., and Morrison, H. 2003. Reactive oxygen species formation by UVA irradiation of UA and the role of trace metals in this chemistry. 

P.K. Shukla et al., H203 as a reactive oxygen species formation of 8-oxoguanine from its reaction with guanine. J. Phys. Chem. B 111, 4603 1615 (2007)... 

Ali SF, LeBel CP, Bondy SC. 1992. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicolgy 13(3) 637-648. 

LeBel CP, Ali SF, Bondy SC. 1992. Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain. Toxicol Appl Pharmacol 112(1) 161-165. 

LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2, 7 -dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992 5 227-31. 

Loss in nutritional value of protein Formation of undesirable colors md flavors Formation of reactive oxygen species Formation of carcin< enic products Formation of mutagenic products Formation of advanced glycation end-products... 

Kristiansen, K.A., Jensen, P.E., Mpller, I.M., Schulz, A., 2009. Monitoring reactive oxygen species formation and localisation in living cells by use of the fluorescent probe CM-H2DCFDA and confocal laser microscopy. Physiol. Plant. 136, 369—383. 

Aminosalicylic acid in assessment of reactive oxygen species formation by in vitro Fenton and ozonation reactions and by in vivo ozone-exposure experiments in rats revealed oxidation products as follows salicylic acid, by deamination 2,3-dihydro-xybenzoic acid and 2,5-dihydroxybenzoic acid, from radical or enzymatic hydroxylation 5-amino-2 - hydroxy-N,W-bis(3 - carboxy- 4- hydroxyphenyl)-1,4-benzoquinonediimine, a condensation product of oxidised 5-aminosalicylic acid and 5-amino-2,3,4,6-tetrahydroxybenzoic acid, attributed to hydroxyl radical attack without deamination, identified by high-pressure liquid chromatography electrochemical detector system analysis and by gas chromatography-mass spectrometry analysis of trimethyl silyl derivatives (Kumarathasan et al. 2001). 

Copper is stored by the liver in the storage protein metallothionein and excreted by the transport protein ceruloplasmin into the bile. When 10 rat hepatocytes were incubated with 50 piM Cu " for 2 h, the formation of reactive oxygen species as determined by oxidation of dichlorofluorescin diacetate to dichlorofluorescein increased from 90 5 intensity units in the controls to 412 9 intensity units in the metal-treated cells (Pourahmad and O Brien 2000). Malondialdehyde UV absorption increased from 0.048 0.006 to 0.662 0.012 units obtained at X ax = 532 nm (P <0.001). The ED50 concentrations found for Cu and Cd (i.e. 50% membrane lysis in 2 h) were 50 and 20 pM, respectively (Pourahmad and O Brien 2000). However, reactive oxygen species formation, GSH oxidation and hpid peroxidation were induced by Cu at these concentrations more rapidly than by Cd. The dechne of mitochondrial membrane potential though occurred at the same time and to the same extent for both metals. 

Dose-dependent reduction of reactive oxygen species formation, lipid peroxidation, and DNA fragmentation... 

Com oil contains natural antioxidants such as tocols, carotenoids and polyphenols. These compounds prevent protein oxidation, lipid peroxidation (Figure 7) and reactive oxygen species formation. 

Aam, B. B. Fonnum, F. (+/-)-2-Chloropropionic acid elevates reactive oxygen species formation in human neutrophil granulocytes. Toxicology 2006, 228, 124-134. 

Vachier 1, Chanez P, Le Doucan C, Damon M, Descomps B, Godard P. Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients. Eur Respir J 1994 7 1585-1592. 

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