Reactive oxygen species induced

Meurer, S., S. Pioch, S. Gross, and W. Muller-Esterl. 2005. Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive gua-nylyl cyclase. J. Biolog. Chem. 280 33149-56. 

Mitochondrial oxidative stress and mitochondrial GSH defense affects transcription factor activation. Oxidant stress in mitochondria not only can promote the loss of mitochondrial GSH and mitochondrial functions, but also can promote extramito-chondrial activation of NF-kB and therefore may affect nuclear gene expression. Mitochondria are targets of cytokines leading to the overproduction of reactive oxygen species induced by ceramide, a lipid intermediate of cytokine action and closely associated with apoptosis. Chronic ethanol intake depletes liver mitochondrial glutathione due to an ethanol-induced defect in the transport of GSH from cytosol into the mitochondrial matirix. This sensitizes liver cells to the prooxidant effects of cytokines and prooxidants generated by the oxidative metabolism of ethanol. 

Lead-induced hyperuricemia may contribute to chronic lead nephropathy. Uric acid per se induces endothelial cell injury, renal microvascular disease, and hypertension, at least in part mediated by oxidative stress [38]. Independent of uric acid, reactive oxygen species induced by lead have been imphcated in endothelial cell injury, increased vascular reactivity, and the production of hypertension in humans and experimental animals [39]. 

Ramachandiran, S., Huang, Q., Dong, J., Lau, S. S., and Monks, T. J. (2002). Mitc en-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial... 

Decreased Complex I activity in fatty liver mitochondria isolated from rats fed with a choline-deficient diet to model in animals nonalcoholic fatty liver disease could also be completely restored to the level of control livers by exogenously added CL (Petrosillo et al., 2007). Under conditions of a choline-deficient diet the mitochondrial content of CL decreased due to reactive oxygen species-induced CL oxidation. Although no high-resolution crystal structure of the entire Complex I is available, these findings strongly suggest the presence of functionally important CL molecules in the complex. 

Toyokuni, S., Reactive oxygen-species-induced molecular damage and its application in... 

Tikoo K, Lau SS, Monks TJ. Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced death in renal proximal tubular epithelial cells. Mol Pharmacol... 

Kagiya, G., Ogawa, R., Tabuchi, Y., Feril Jr, L. B., Nozaki, T., Fukuda, S., Yamamoto, K., Kondo, T. (2006). Expression of heme oxygenase -1 due to intracellular reactive oxygen species induced by ultrasound. Ultrason. Sonochem., 13(5), 388-396. 

Yin H, Casey PS, McCaU MJ, Fenech M. Effects of surface chemistry on cytotoxicity, genotoxicity, and the generation of reactive oxygen species induced by ZnO nanoparticles. Langmuir 2010 26 15399-408. 

Reactive oxygen species induced within the pancreatic B cells by alloxan are involved in the pathogenesis of type I diabetes mellitus, while extracellular generation of reactive oxygen species by the xanthin-xanthin oxidase system only retarded insulin release from the B cells (Ebelt et al. 1999). Melatonin protected B cells from alloxan-induced lesion in vitro. 

However, leucocyte-derived reactive oxygen species induce far greater yields of base modifications... 

Legault, J., W. Dahl, E. Debiton, A. Pichette, and J.-C. Madehnont, 2003. Antitumor activity of baslam firoU Production of reactive oxygen species induced by a-humulene as possible mechanism of action. Planta Med, 69(5) 402-107. 

Valencia, A. and Moran, J. 2004. Reactive oxygen species induce different cell death mechanisms in cultured neurons. Free radical biology medicine, 36(9), 1112-25. 

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