Rats, flatulence

Coriandrum sativum L. Conundrum sativum L. (coriander) belongs to the Apiaceae family and is cultivated worldwide for its nutritional value and medicinal properties (relief of pain, anxiety, flatulence, loss of appetite, and convulsions). The effects of inhaled coriander volatile oil (1-3 %) extracted from Coriandrum sativum var. microcarpum on spatial memory performance were assessed in an Ap2 2 rat model of AD. Exposure to coriander volatile oil improved spatial memory, increased superoxide dismutase (SOD), lactate dehydrogenase (LDH), and decreased glutathione peroxidase (GPX) specific activities along with an elevation of malondial-dehyde (MDA) level [288],... 

Figure 10. Flatulence in rats produced by California small white beans which had been allowed to autolyze for different times at pH 5.2 and 55°C (47)...

Bengal. In the Ayurvedic system of medicine, it is said to be useful in flatulence, cold, rheumatism, intestinal worms, anemia, fever and jaundice. The outstanding effect of arborine, isolated from this plant, is inhibition of the peripheral action of acetylcholine on rat uterus, on guinea pig ileum and on skeletal muscle. It also markedly inhibits the action of pituitrin on the rat uterus. The arborine-induced fall in blood pressure in the intact cat is central in origin, being absent in the spinal cat, but present in the vagotomized animal 37, 43). 

Toxicoiogy LD50 (oral, rat) > 4 g/kg, (IP, rat) > 1600 mg/kg, (subcut., rat) > 1200 mg/kg may be harmful by inh., ing., or skin absorp. exposure may cause nausea, abdominal discomfort, indigestion, constipation, vit. A/D/K deficiencies, rash, mucous membrane irritation, osteoporosis, flatulence, vomiting, diarrhea, heartburn, anorexia TSCA listed Precaution Probably combustible avoid heat... 

Toxicology LD50 (oral, rat) 13,500 mg/kg, (IV, rat) 9690 mg/kg, (IP, mouse) 14 g/kg, (IV, mouse) 7470 mg/kg mildly toxic by ing., IP, IV routes human systemic effects by IV route (raised blood pressure, bladder tubule changes, nausea, vomiting) excess consumption may have a laxative effect may cause diarrhea and flatulence human mutagenic data TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and fumes Storage Hygroscopic store R.T. 

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