Rapid-dissolving tablets

Use rapid-dissolving tablet (Parcopa ), crush Sinemet , or make liquid Sinemet ... 

Substitute or add rapid-dissolving tablet form or liquid form of Sinemet ... 

Gl lesions Potassium chloride tablets have caused stenotic or ulcerative lesions of the small bowel and death. These lesions are caused by a concentration of potassium ion in the region of a rapidly dissolving tablet, which injures the bowel wall and produces obstruction, hemorrhage, or perforation. The reported frequency of small bowel lesions is much less with wax matrix tablets and microencapsulated tablets than with enteric coated tablets. Immediately discontinue either type of tablet and consider the possibility of bowel obstruction or perforation if severe vomiting. 

Of the range of pharmaceutic preparations available for administration into the oral cavity, the most popular form is that of a rapidly dissolving tablet that releases its drug contents for absorption across the oral mucosa. Alternatively, a tablet or capsule can be chewed to release its contents. This latter method is less successful because mastication tends to produce a large volume of saliva that increases the probability of premature swallowing. The same problem occurs in the administration of drug in the form of a chewing gum. 

Hard shell capsules have often been assumed to have better bioavailability than tablets. Most likely this assumption derives from the fact the gelatin shell rapidly dissolves and ruptures, which affords at least the potential for rapid release of the drug, together with the lack of utilization of a compaction process comparable to tablet compression in filling the capsules. However, capsules can be just as easily malformulated as tablets. A number of cases of bioavailability problems with capsules have been reported [5-8],... 

For prophylaxis when undertaking activities that predictably precipitate attacks, nitroglycerin 0.3 to 0.4 mg sublingually may be used about 5 minutes prior to the time of the activity. Nitroglycerin spray may be useful when inadequate saliva is produced to rapidly dissolve sublingual nitroglycerin or if a patient has difficulty opening the tablet container. The response usually lasts about 30 minutes. 

The highly lipid soluble and nonirritating drugs (i.e. nitroglycerine, isoprenaline, methyltestosterone) in the form of tablets or pellet is placed under the tongue, where they rapidly dissolve and are absorbed quickly in the general circulation. The advantages of this routes are ... 

Rapidly dissolving Eilms or compressed powders that contain drugs tablets or films that are rapidly released in the mouth. Limited... 

Apart from immediate release tablet formulations, neural networks have also been applied to modeling immediate release capsule formulations and rapidly disintegrating or dissolving tablets. In the latter, Sunada and Bi from Japan used both statistics and neural networks to optimize both the formulation and processing conditions for rapidly disintegrating tablets developed using both direct compression and wet granulation techniques. 

Layered tablets are also used for a prolonged or sustained therapeutic effect. In this case, one layer disintegrates and dissolves rapidly to provide the initial dosing, whereas the other is designed for controlled release. 

ChlorinatedIsocya.nura.tes. The cyanuric acid-based sanitizers, introduced for pool use in 1958, are stable crystalline compounds with moderate-to-high available CI2. Sodium dichloroisocyanurate (Dichlor), sold in granular form, dissolves rapidly, whereas trichloroisocyanuric acid (Trichlor) dissolves very slowly and is widely used in the form of tablets or sticks in feeders, floating devices, or in the pool skimmer. 

Bismuth subsalicylate—Immediately report any symptoms of salicylate toxicity (ringing in the ears, rapid respirations). Chew tablets thoroughly or dissolve them in the mouth. Do not swallow tablets whole Stools may become dark. This is normal and will disappear when tiie drug therapy is discontinued. Do not take this drug with aspirin or aspirin products. 

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