Nitroglycerin spray

For prophylaxis when undertaking activities that predictably precipitate attacks, nitroglycerin 0.3 to 0.4 mg sublingually may be used about 5 minutes prior to the time of the activity. Nitroglycerin spray may be useful when inadequate saliva is produced to rapidly dissolve sublingual nitroglycerin or if a patient has difficulty opening the tablet container. The response usually lasts about 30 minutes. 

Sublingual nitroglycerin tablets or nitroglycerin spray may be used for patients who develop shortness of breath with mild exercise, and they may be used much in the same way as in patients with ischemic symptoms. Nitroglycerin will decrease LV end-diastolic volume resulting in relief of breathlessness. 

The nitrates are available in various forms (eg, sublingual, transmucosal, translingual spray, and inhalation). Some adverse reactions are a result of the metiiod of administration. For example, sublingual nitroglycerin may cause a local burning or tingling in the oral cavity. However, die patient must be aware that an absence of this effect does not indicate a decrease in the drug s potency. Contact dermatitis may occur from use of die transdermal delivery system. 

Nitroglycerin may also be administered by a metered spray canister tiiat is used to abort an acute anginal attack. The spray is directed from the canister onto or under the tongue. Each dose is metered so that when the canister top is depressed, the same dose is delivered each time. The nurse instructs the patient not to inhale die spray. For some individuals, this is more convenient dian die small tablets placed under the tongue... 

The dose of sublingual nitroglycerin may be repeated every 5 minutes until pain is relieved or until the patient has received three doses in a 15-minute period. One to two sprays of translingual nitroglycerin may be used to relieve angina, but no more than three metered doses are recommended within a 15-minute period. 

Figure 1 indicates a typical nitroglycerin facility "inside out" wood frame construction at a concrete floor slab. Note that the exterior cant strip, the lead conductive floor cant and the wood cap are all sloped to discourage product build-up and facilitate cleaning. This assembly also indicates spray-on foam insulation as an optional construction item. At Radford AAP this is a safety approved insulation system. The insulation at Radford AAP received a chlorinated rubber paint coating for weathering. 

Acute angina (nitroglycerin sublingual ortranslingual spray isosorbide din it rate sublingual amyl nitrite) For relief of acute anginal episodes prophylaxis prior to events likely to provoke an attack. 

Angina prophylaxis (nitroglycerin topical, transdermal, translingual spray, oral... 

NITROGLYCERIN, TRANSLINGUAL At the onset of attack, spray 1 or 2 metered doses onto or under the tongue. No more than 3 metered doses are recommended within 15 minutes. May use prophylactically 5 to 10 minutes prior to activities which might precipitate an acute attack. Do not inhale spray. 

Nitroglycerin, the prototype of the nitrates is characterized by a rapid onset and short duration of action. It is usually administered sublingually (via the oro-mucosal route), which allows a rapid and efficient absorption and avoids the strong first pass effect after oral administration. Nitroglycerin is available as tablets, capsules (for sublingual administration) but also as transdermal preparations, sprays, and ointments. 

Nitrolingual Pumpspray (nitroglycerin lingual spray 400 meg) is a metered-dose spray containing nitroglycerin. This product delivers nitroglycerin (400 meg per spray, 75 or 200 metered sprays) in the form of spray droplets... 

The substance of a sheath is better sprayed after the detonation owing to the presence of nitroglycerine taking part in the detonation and since it is then better mixed with the detonation products of the explosive ... 

Dense ammonium nitrate crystals are formed by spraying droplets of molten ammonium nitrate solution (>99.6%) down a short tower. The spray produces spherical particles known as prills . These crystals are non-absorbent and used in conjunction with nitroglycerine. An absorbent form of ammonium nitrate can be obtained by spraying a hot, 95% solution of ammonium nitrate down a high tower. The resultant spheres are carefully dried and cooled to prevent breakage during handling. These absorbent spheres are used with fuel oil. 

Lipid aerosol formulations of nitroglycerin are also available, which are far more stable than the tablets, with a prolonged (3-year) shelf life. Sprayed directly onto the tongue, they produce relief of anginal pain within 2 min with a duration of effect of up to 30 min. However, it has been shown that the use of different aerosol vehicles markedly influences the bioavailability of the dmg, which obviously has important therapeutic implications. 

Nitrates, (3-blockers, and calcium channel blockers are equally effective for relief of anginal symptoms. However, for prompt relief of an ongoing attack of angina precipitated by exercise or emotional stress, sublingual (or spray form) nitroglycerin is the drug of choice. 

Nitroglycerin (NTC) is distinguished by a high membrane penetrability and very low stability. It is the drug of choice in the treatment of angina pectoris attacks. For this purpose, it is administered as a spray, or in sublingual or buccal tablets for transmucosal delivery. The onset of action is between 1 and 3 minutes. Due to a nearly complete presystemic elimination, it is poorly suited for oral administration. Transdermal delivery (nitroglycerin patch) also avoids presystemic elimination. 

Of the approximately 12 motion pictures we made of the impact initiation process, all show that the structure of the air bubble is broken down and replaced by a turbulence area. Ignition occurs at the former site of the bubble after an induction period. The compression ratio of the air bubble appears to be the major factor determining probability of initiation by impact. The mechanism for impact initiation of nitroglycerin therefore appears to be a quasi-adiabatic compression of the gas, with heat transfer accelerated by spray formation. Hot spots formed at the former site of the bubble undergo an accelerating exothermic reaction which proceeds to a deflagration. The possibility that liquid explosives under reduced pressure may be sensitized to weak impacts must be considered. 

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