Randomized controlled trials antipsychotics

Clozapine randomized, controlled trials versus typical antipsychotic drugs. 

Jones, P. B., Barnes, T. R., Davies, L., Dunn, G., Lloyd, H., Hayhurst, K. P., Murray, R. M., Markwick, A., Lewis, S. W. 2006, Randomized controlled trial of the effect on quality of Life of second- vs first-generation antipsychotic dmgs in schizophrenia Cost utility of the latest antipsychotic drugs in schizophrenia study (Cutlass 1), Arch.Gen.Psychiatry, vol. 63, no. 10, pp. 1079-1087. 

Scherk, H., Pajonk, R G., Leucht, S. 2007, Second-generation antipsychotic agents in the treatment of acute mania a systematic review and meta-analysis of randomized controlled trials, Arch.Gen.Psychiatry, vol. 64, no. 4, pp. 442-455. 

Leucht S, Pitschel-Walz G, Abraham D, Kissling W. Efficacy and extrapyramidal side-effects of the new anti-psychotics olanzapine, quetiapine, risperidone, and sertin-dole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res 1999 35(1) 51—68. 

Leucht S. Amisulpride - a selective dopamine antagonist and atypical antipsychotic results of a meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol 2004 7 Suppl 1 S15-S20. 

Leucht S, Pitschel-Walz G, Engel RR, Kisshng W. Amisulpride, an unusual atypical antipsychotic a metaanalysis of randomized controlled trials. Am J Psychiatry 2002 159(2) 180-90. 

Leucht S, Barnes TR, Kissling W, et al. Relapse prevention in schizophrenia with new-generation antipsychotics A systematic review and exploratory meta-analysis of randomized, controlled trials. Am J Psychiatry 2003 160 1209-1222. 

Comparative studies Quetiapine 375 mg/day and risperidone 2.72 mg/day have been compared in 72 patients with a first episode of a schizophreniform psychosis with less than 2 weeks of exposure to antipsychotic drugs in a single-blind, 12-week, randomized, controlled trial [120 ]. Both drugs reduced immediate symptoms and there were relatively few adverse reactions other than weight gain. The median time to cessation for patients randomized to quetiapine was 65 days and for risperidone 83 days, and this difference was not significantly different. 

Gentile S. Second-generation antipsychotics in dementia beyond safety concerns. A clinical, systematic review of efficacy data from randomized controlled trials. Psychopharmacology (Berl) 2010 212 119-29. 

Perlis RH, Welge JA, Vornik LA, et al. Atypical antipsychotics in the treatment of mania a meta-analysis of randomized, placebo-controlled trials. J Clin Psychiatry 2006 67 509-516. 

Although most controlled trials lasted only weeks, the longitudinal study of the effect of psychotherapy versus drugs by May et al. ( 20, 21) is particularly germane. Schizophrenic patients were randomly assigned to either antipsychotics or no medication. After 6 months or more, the initial nonmedication group was then given... 

Klein, D., Cottingham, E., Sorter, M., Barton, B., Morrison, J. (2006). A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. American Journal of Psychiatry, 163, 2072-2079. 

Schneider LS, Dagerman KS, Insel P. Efficacy and adverse effects of atypical antipsychotics for dementia meta-ana-lysis of randomized, placebo controlled trials. Am J Geriatr Psychiatry 2006 14 191-210. 

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