Raman optical activity,

Barron L D, Hecht L, Bell A F and WIson G 1996 Raman optical activity an incisive probe of chirality and biomolecular structure and dynamics ICORS 96 XVth Int. Conf. on Raman Spectroscopy ed S A Asher and P B Stein (New York Wley) pp 1212-15... 

Hecht L and Barron L D 1996 Raman optical activity Modern Techniques in Raman Spectroscopy ed J J Laserna (New York Wley) pp 265-342... 

Barron, L. D., and Vrbancich, J. Natural Vibrational Raman Optical Activity. 123,151-182 (1984) Bestmann, H. J., Vostrowsky, O. Selected Topics of the Wittig Reaction in the Synthesis of Natural Products. 109, 85-163 (1983). 

Barron, L. D., and Vrbancich, J. Natural Vibrational Raman Optical Activity. 123, 151-182 (1984). 

UNFOLDED PROTEINS STUDIED BY RAMAN OPTICAL ACTIVITY... 

B. Enhanced Sensitivity of Raman Optical Activity to Structure... 

III. Survey of Polypeptide and Protein Raman Optical Activity. 59... 

B. Raman Optical Activity Band Assignments for Folded Proteins. 60... 

Raman optical activity is an excellent technique for studying polypeptide and protein structure in aqueous solution since, as mentioned above, their ROA spectra are often dominated by bands originating in the peptide backbone that directly reflect the solution conformation. Furthermore, the special sensitivity of ROA to dynamic aspects of structure makes it a new source of information on order-disorder transitions. 

Raman optical activity has proved valuable in recent studies of the structure and behavior of a number of natively unfolded proteins found in quite different biological situations. Although completely unfolded, the structures appear to be more stable than those generated by complete unfolding of proteins having a tertiary fold in their native states. Such natively unfolded proteins clearly have special characteristics built into their amino acid sequences that prevent aggregation under normal physiological conditions. 

F. Evidence from Vibrational Raman Optical Activity Studies. 198... 

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