Turns, Raman optical activity

In the last two decades, interest has also turned to the possible use of Raman optical activity (ROA) as an additional probe into the stereochemistry of chiral molecules157. The... 

Outside of the occasional system calibration and model verification tests, the routine maintenance burden of a Raman system is quite low. Optical windows may need to be cleaned, though automatic window cleaning systems can be implemented if it is a known issue. The most likely maintenance activity is laser replacement. Some systems have a backup laser that turns on automatically if the primary laser fails. This lessens the impact of a failure if the unit is being used for closed-loop process control. With a quality instrument and well-developed models, process Raman installations need less maintenance than many competing techniques. 

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