Radio agent

An interesting set of central nervous system properties has also been discovered and studied (Table VI-10). The work devoted to piscaine must be emphasized besides finding hypnotic properties of 2-amino-4-phenyl-thiazole on fish, the authors studied the structure of the metabolite, as well as the localization of the (radio labeled) metabolic product in various organs. Recently, thiazol-4-yl methoxyamine was shown to inhibit the development of morphine tolerance (1607). 5-Aminothiazole derivatives such as 419a were proposed as cardiovascular agents (1608, 1610). Substitution of the 5-aminothiazole radical on the cephalophosphorin structure gives a series of antibacterial products (1609). 

Cesium was first produced ia the metallic state by electrolysis of a molten mixture of cesium and barium cyanides (2). Subsequentiy the more common thermochemical—reduction techniques were developed (3,4). There were essentially no iadustrial uses for cesium until 1926, when it was used for a few years as a getter and as an effective agent ia reduciag the electron work function on coated tungsten filaments ia radio tubes. Development of photoelectric cells a few years later resulted ia a small but steady consumption of cesium and other appHcations for cesium ia photosensing elements followed. 

Electroless nickel or nickel—lead alloys can improve the solderabiUty and braisabiUty of aluminum even when a continuous film is not present. Electroless nickel systems based on dimethylaminehorane reduciag agents are used to coat aluminum contacts and semiconductors (qv) ia the electronics iadustry. Newer uses iaclude corrosion-resistant electroless nickel topcoatings on electroless copper plating for radio frequency... 

Radio-tracers have been used to study silver deposition, and it has been shown that when certain inhibitors or complexing agents are present the displacement reaction may be markedly affected ... 

The role of the platelet integrin GPIIb/IIIa receptor and its potential utility as a radio-diagnostic agent in the rapid detection of thromboembolic events has been demonstrated [6]. This approach may be useful for the noninvasive diagnosis of various thromboembolic disorders. 

Gutierrez, P. L. The role of NAD(P)H oxidoreductase (DT-diaphorase) in the bioactivation of quinone-containing antitumor agents a review. Free Radio. Biol. Med. 2000, 29, 263-275. 

Liu S (2005) 6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for "mTc-Labeling of Small Biomolecules. 252 117-153 Liu S, Robinson SP, Edwards DS (2005) Radiolabeled Integrin avp Antagonists as Radio-pharmaceuticals for Tumor Radiotherapy. 252 193-216 Liu XY (2005) Gelation with Small Molecules from Formation Mechanism to Nanostructure Architecture. 256 1-37... 

For many years, clinical development of PARPi has focused on evaluating their potential as chemo- and radio-potentiating agents. However, clinical trials have recently been initiated to investigate single agent activity in specific subpopulations [40,41]. 

Fig. 34. Model of a functionalised (internally or externally) SWNT, which may be closed, open and/or corked reversibly or permanently after filling. Potentially the inner cavity may be filled with a (radio)-imaging agent (for PET/SPECT and/or MRI) or a (radio)therapeutic agent. Such functionalized SWNTs may conceivably act as probe prototype for multimodal imaging/therapy and targeted drug delivery (155).

Vesicants are also systemic agents and readily pass through the skin to affect susceptible tissue including those that produce blood. For this reason they are often described as radio-mimetic poisons. In severe cases, systemic effects can include cardiovascular shock and multiorgan failure. Nitrogen vesicants can also cause central nervous system depression and cardiovascular shock. Both sulfur and nitrogen vesicants are carcinogenic. 

M90 Automatic Agent Detector (AMAD) An automatic nerve and mustard agent detector that detects agents in vapor form. It transmits an alarm by radio to a central alarm unit. It is currently used in the Air Force. 

Oxidative degradation can be the most serious problem in the use of plastics at higher temperatures. At ambient temperature oxidation proceeds relatively slowly on its own, but can be stimulated by light (photo-oxidation), ionising radiation (radio-oxidation), certain gaseous and liquid environments and by the presence of transition metals. The rate at which oxidation occurs will therefore depend on the intensity of these agents, on temperature, and on the availability of oxygen, which in turn depends upon its solubility, its rate of diffusion (see Section 4.12.2) and the rate at which it is consumed. 

Other examples cited by Goodman include the poisoning of 200 French soldiers by Chinese reformers in Hanoi on 27 June 1908, all of whom recovered. One of the intoxicated soldiers saw ants on his bed, a second fled to a tree to escape from a hallucinated tiger and a third took aim at birds in the sky. Another incident was the abortive attempt by Soviet agents in 1959 to poison the staff of Radio Free Europe in Munich by putting atropine in saltshakers in the cafeteria. A double agent foiled this effort. 

Gastrointestinal transit time by hydrogen breath test and radio-opaque markers Gastrointestinal motiUty agents... 

Uses. As strong reducing agent in manufacture of high-frequency coils used in radios and televisions as antiknock agent in motor fuels... 

For common preclinical laboratory specimens such as mouse and rat, it is possible to image the skeletal features associated with different developmental stages of serial end-point harvested specimens (Fig. 1). Additionally, with the use of radio-opaque contrast agents, it is possible to image capture the soft tissue features of these specimens (Fig. 2). The combined imaging can be used to illustrate various anatomical features of interest within the same specimen (Fig. 3). This imaging technique therefore has an added potential of conferring multi-modality to an individual micro-CT machine. 

Fowles, E.H., Gilbert, B.C., Giles, M.R. and Whitwood, A.C. (2007) The effects of chelating agents on radical generation in alkaline peroxide systems, and the relevance to substrate damage. Free Radio. Res., 41, 515-522. 

---