Multiorgan failure

One woman died after 1 week, with multiorgan failure despite intravenous dimercaptosuccinic acid chelation. The other gradually recovered from severe neuropsychiatric symptoms over several months. She had been chelated for several weeks with oral dimercaptosuccinic acid, which apparently improved her clinical condition. ... 

The importance of CD28 came out when the phase I clinical trial with the humanized monoclonal superagonist of the CD28, TGN1412, resulted in an unexpected cytokine storm with multiorgan failure in 2006 in the UK [71],... 

Type II NF is generally a monomicrobial infection caused by invasive GAS. Occasionally S. aureus is implicated. Type II often occurs after minor trauma, such as an insect bite or abrasion.3 It is more severe than type I because invasive strains of GAS produce toxins that induce erythema, systemic toxicity, multiorgan failure, and shock.22... 

Vesicants are also systemic agents and readily pass through the skin to affect susceptible tissue including those that produce blood. For this reason they are often described as radio-mimetic poisons. In severe cases, systemic effects can include cardiovascular shock and multiorgan failure. Nitrogen vesicants can also cause central nervous system depression and cardiovascular shock. Both sulfur and nitrogen vesicants are carcinogenic. 

Role for disease Released mediators cause fever, hypotension, tachycardia, tachypnea, systemic shock, and multiorgan failure not dependent upon the bacterial species Depends upon the individual intravascular coagulation, leucopenia, toxin/bacterium (see Table 2)... 

Ischemic acute renal failure (ARF), characterized by a sharp decline of glomerular filtration rate, is a very common complication in hospitalized patients and particularly in patients with multiorgan failure. Although it develops most frequently in multimorbid patients, its occurrence per se increases the risk of death by 10- to 15-fold (Ghertow et al, 1998). This unacceptable situation in both diseases warrants the urgent development of new treatment modalities. 

A 62-year-old man took amiodarone for 2 years and developed hyperthyroidism carbimazole 40 mg/day, prednisolone, lithium, and colestyramine were ineffective and he died with hepatic encephalopathy and multiorgan failure. 

Organization of material in monographs in the Meyler series (not all sections are included in each monograph) Body temperature Multiorgan failure... 

K.C. Trent, et al., Multiorgan failure associated with lomustine oversode. Ann. Pharmacother. 29 384-386, 1995. 

Miettinen PJ, Berger IE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995 376 337 41. 

Body temperature Multiorgan failure Trauma Death... 

These granulomatous tubercles are surrounded by a loose rim of lymphocytes. Massive miliary spread to the liver may also cause acute liver failure (35, 44) as well as septic shock with multiorgan failure. (54)... 

J. L., Banaji, M., Hardin, B.J., Shulman, HJM., Clift, R.A. Veno-occlusive disease of the Hver and multiorgan failure after bone marrow transplantation a cohort study of 355 patients. Ann. Intern. Med. 1993 118 255-267... 

Five patients developed severe symptoms after receiving cefepime (31). The patients, three men and two women, aged 16-75 years, received 2 g/day (n — 3) A g/day n = 1) or 9 g/day n — 1). The symptoms started 12-16 days after the start of therapy. In all cases, the initial neurological symptoms (disorientation, confusion, and reduced consciousness) were progressive and were attributed to the infection. Facial or multifocal myoclonic movements occurred subsequently and were rapidly followed by convulsive or non-convulsive status epilepticus. The dose of cefipime had not been adjusted for renal function in any of the patients. Cefepime serum concentrations were measured in three cases, and were 72, 73, and 134 gg/ml. All the patients underwent hemodialysis, and the serum concentrations of cefepime fell to 4.3, 21, and 25 gg/ml respectively. In the other two patients, the serum concentrations after dialysis were 14 and 54 gg/ml, suggesting high concentrations before dialysis. There was complete recovery in four of the patients. One, a 73-year-old woman, died of multiorgan failure with refractory status epilepticus and coma. The authors referred to four... 

A 39-year-old woman with rheumatoid arthritis took hydroxychloroquine 200 mg bd for painful synovitis, in addition to meloxicam, co-dydramol, and Gaviscon. She inadvertently took twice the prescribed dose of hydroxychloroquine, but stopped it after 2 weeks because of nausea. The next day she developed a widespread blotchy erythema and 2 weeks later was admitted to hospital with clinical and histological toxic epidermal necrolysis and deteriorated rapidly with multiorgan failure she died 1 week later. 

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