Rabbits, transgenic

Stromqvist M, Houdebine L, Andersson J, et al. Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits. Transgenic Res., 1997 6(4) 271-278. 

In addition to milk, a range of recombinant proteins have been expressed in various other targeted tissues/fluids of transgenic animals. Antibodies and other proteins have been produced in the blood of transgenic pigs and rabbits. This mode of production, however, is unlikely to be pursued industrially for a number of reasons ... 

In the case of spontaneous autoimmune diseases mice are the most frequently used animal model. With the advent of transgenic and genetically modified (knockout, KO) mice, the number of genetically predisposed autoimmune models has substantially increased. Other species that have been useful include rats, monkeys, cats, dogs, rabbits, and chickens for some specific forms of autoimmune diseases [4, 5]. 

Further comparative studies of LI expression were conducted in transgenic plants versus a TMV expression vector. In this case, the cottontail rabbit papillomavirus (CRPV), a close relative of HPV, was used. Rabbits vaccinated with purihed protein were protected against wart development upon challenge with live CRPV despite the fact that VLPs were not detected in this animal model system (Kohl et al., 2006). 

Gil, F., Titarenko, E., Terrada, E., Arcalis, E., and Escribano, J.M. (2006). Successful oral prime-immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies. Plant Biotechnol. J. 4(10) 135-143. 

Martin-Alonso, J.M., Castanon, S., Alonso, R, Parra, E, and Ordas, R. (2003). Oral immunization nsing tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res. 12 127-130. 

Transgenic pig. rabbit, and sheep by micro injection of foreign DNA iiitu egg nuclei. 

There are alternative explanations of how the muscarinic receptor activates PI3 kinase. Tong et al.47 propose that the coupling somehow involves receptor internalization as transgenic mutant mice in which receptor internalization was blocked could not be preconditioned. Miura s group proposes that the metalloproteinase liberates TNF rather than EGF.48 In our rabbit cardiomyocyte model, however, the evidence for EGF coupling seems very strong.49... 

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