Quantitation targets

Quantitative targets or limits, as these are the domain of quality objectives... 

QqQ MS) are, on the other hand, a good option for sensitive, quantitative targeted analysis using multiple reaction monitoring (MRM), and they can also be used for class-specific detection through precursor ion and neutral loss scanning (4-6). 

Bailey, G.S., R. Dashwood, P.M. Loveland, C. Pereira and J.D. Hendricks. Molecular dosimetry in fish quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout. Mutat. Res. Fund. Mol. Mech. Mutagen. 399 233-244, 1998. 

There are four companywide targets, two relating to safety guidelines and procedures, one to occupational health procedures, and a quantitative target for accidents. There are also many sitewide targets, which vary in quality from site to site, but in general they are quantitative. 

According to the previous discussions it follows that the quantitative target for the top hazard is set to 2.0 10 /hoiu-/train. This safety target is defined in the Technical specification for interoperabihty (TSI) for Control-Command and signalling, and is a legal requirement, see EC (2006). 

A quantitative target for measuring the level of performance needed for safety function to achieve a tolerable risk for a process hazard. It is a measure of safety system performance, in terms of the probability of failure on demand. There are four discreet integrity levels, SIL 1-4. The higher the SIL level, the higher the associated safety level and the lower the probability that a system will fail to perform properly. Defining a target SIL level for a process should be based on the assessment of the likelihood that an incident will occur and the consequences of the incident. Table S.2 describes SIL for different modes of operation. 

Structure elucidation Simple quantitation Targeted screening... 

Yocum, A.K., Chinnaiyan, A.M. (2009) Current Affairs in Quantitative Targeted Pro-teomics Multiple Reaction Monitoring-Mass Spectrometry. Brief. Eunct. Genom. Proteom. 8 145-157. 

A question sometimes asked is If the quantitative target is met by the predicted random hardware failure probability then what allocation should there be for the systematic (software) failures The target is to be applied equally to random hardware failures and to systematic failures. In other words the numerical target is not divided between the two but applied to the random hardware failures. The corresponding SIL requirements are then applied to the systematic failures. In any case, having regard to the accuracy of... 

This requirement applies to ASIL (B), C, and D of the safety goal. Quantitative target values for the maximum probability of the violation of each safety goal due to random hardware failures as required in ISO 26262-4 —i J.4.4.3 shall be defined using one of the sources (a), (b) or (c) of reference target values as outlined below. 

NOTE These quantitative target vaiues described in this tabie can be taiiored as given in 4.1 to fit specific uses of the item (for instance if the item is abie to vioiate the safety goai for durations ionger than the typicai use of a ... 

The target product quality profile (TPQP) provides quantitative descriptions of clinical safety and efficacy that can be utilized to design and optimize a drug product. Because it describes aspects of clinical safety, the TPQP should comprise quantitative targets for attributes that are related to product performance. Examples include stability requirements and release profiles as these attributes are specifically related to the product s performance. It must be noted that the TPQP is not a specification because it may include analyses that are not required for batch release. Effectively, the TPQP serves as the interface between the prod-uct/process and the patient, where performance characteristics of the product relevant to the clinical performance are quantified. Providing the link between the clinical performance and the process is essential in the QbD paradigm because pharmaceutical quality is defined such that risk to the consumer is minimized and the product performance is commensurate with the label. 

II.2. Although no universal quantitative targets can be expressed for the individual leU-abihty requirements for each level of defence in depth, the greatest emphasis should be placed on the first level. This is also consistent with the objective of the operating organization that there should be high availability of the plant for power productioa... 

Road safety policy formulation showed the largest degree of consensus between countries, especially with regards to the presence of a road safety strategy with specific quantitative targets for fatality reduction. Nevertheless, several inconsistencies and uncertainties are involved in the adoption of road safety programs and the participation or consultation of regional and local authorities. 

D. M. Jacobs, E. van Velzen and V. Mihaleva, Evaluation of Approaches for Quantitative Targeted Profiling of Complex Compositions Using ID h NMR Spectroscopy, in Magnetic Resonance in Food Science, ed. J. van Duynhoven, P. S. Belton, G. A. Webb and H. van As, Special Publication -Royal Society of Chemistry, Royal Society of Chemistry, 2013, vol. 343, p. 3. 

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