Proteins ginkgo

Siddique MS, Eddeb F, Mantle D and Mendelow AD (2000). Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro. 

Amri H, Drieu K, Papadopoulos V. (1997). Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract EGb 761 and isolated ginkgolide B. Endocrinology. 138(12) 5415-26. 

Bastianetto, S., Zheng, W.-H., and Quirion, R., The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity involvement of its flavonoid constituents and protein kinase C, J. Neurochem., 74, 2268-2277, 2000. 

Dumont E, Petit E, Tarrade T, Nouvelot A. UV-C irradiation-induced peroxidalive degradation of microsomal fatty acids and proteins protection by an extract of Ginkgo biloba (EGb 761). Pree Radic Biol Med 1992 13(3) 197-203. 

In healthy volunteers orally administered 100 mg talinolol with a single dose of 120 mg ginkgo leaf extract, no changes in plasma levels of talinolol were observed. After repeated dosing for 14 days with 360 mg of the same ginkgo leaf extract daily, plasma levels of talinolol were increased. Talinolol is a substrate of the drug transporter protein P-gp (Fan et al. 2009). 

Prod, by fungus F-23372. Also prod, by Rhizoctonia solani found on the bark of Ginkgo biloba. Protein tyrosine kinase inhibitor. Cytotoxic. Red-orange solid. Mp 265-270° dec. 266 (e 8800), 426 (e 20400) (MeOH). Similar to Aspulvinone G, A-02957. 

The extract of Ginkgo biloba leaves (50 pg/ml) caused a 30 % reduction of NO metabohtes released by a human endothelial cell Une (ECV304) cellular inducible NO synthase (iNOS) activity was reduced by 28 % with a concomitant reduction in the levels of iNOS protein mass and mRNA (Cheung et al. 1999). 

Augustin S, Rimbach G, Augustin K, Schliebs R, Wolffram S, Cermak R (2009) Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursOT protein levels in a transgenic mouse model relevant to Alzheimer s disease. Arch Biochem Biophys 481(2) 177-182. doi 10.1016/j.abb.2008.10.032... 

Ginkgo seeds are listed in Food Composition Table F-21. Overall, they are lower in protein and have fewer calories than most nuts, but they do contain significant amounts of many minerals and vitamins. 

Perhaps the most extensively studied activity of ginkgo is its antioxidant activity and it is probably the key to its significant protective effects. Numerous reports have appeared in recent literature that link such activity to neuroprotection, hepatoprotection, radioprotection,cancer chemoprevention and apoptosis,Alzheimer s disease (amyloid-beta protein inhibition), reduced cerebral ischemia/stroke, gastropro-tection (antiulcer), nephroprotection, reduced mitochondrial stress," "" and even skin disorders (vitiligo)." ... 

Ginkgo s inhibitory effect on the production of amyloid-beta protein has also been mediated by other mechanisms, such as acetylcholinesterase inhibition, modulation of amyloid protein oligomeric species, and lowering of free cholesterol levels." ... 

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