Protein damage

DNA Membrane Oxidative Protein damage damage damage damage... 

Fig. 16.1 Progression of oxidation in a food system from formation of radicals through primary and secondary lipid oxidation products to protein damage.

Detection of Protein Damage Arising the Radical-mediated Peroxidation of ... 

Hunt, J.V., Dean, R.T. and Wolff, S. (1988). Hydroxyl radical production and autoxidative glycosylation. Glucose oxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. Biochem. J. 256, 205-212. 

For tryptophan, there seems to be an equilibrium, which could also lead to some tryptophan radical formation and subsequent protein damage ... 

Davies, K.J.A. (1987) Protein damage and degradation by oxygen radicals. J. Biol. Chem. 262(20), 9895-9901. 

Therefore, the enhancement of protein damage by the H0 + 02 combination is only possible if both free radicals react with proteins independently. 

Lipid Peroxidation DNA Strand Breaks Protein Damage... 

It has long been suggested that ROS may play causal roles in these diseases and in the production of the aberrant protein molecules (de Arriba et al., 2006). In addition, protein damage inflicted by RNS has also been suggested. As discussed above, carnosine has been shown to possess antioxidant activity and also to react with RNS as well, hence the molecule has the potential to be considered as a theraupeutic agent (Calabrese et al., 2008). 

As noted above, carnosine has been shown to inhibit protein damage mediated by peroxynitrite and hydroxyl radicals in astroglial cells (Nicoletti et ah, 2007). There is some evidence that carnosine can suppress some of the oxidative damage associated with PD using a model system, and possibly inhibit fibrillization of a-synuclein (Herrera et ah, 2008). 

Hagerman, A.E., Dean, R.T., and Davies, M.J., Radical chemistry of epigallocatechin gallate and its relevance to protein damage, Arch. Biochem. Biophys., 414, 115, 2003. 

Illumination of bRCs of the carotenoidless mutant R. sphaeroides R-26 leads to a loss of photochemical activity and protein damage in the presence of oxygen. This effect is suppressed in wild-type strain 2.4.1 and also in R-26 when the... 

Oxidation of protein residues arises from a number of different sources. Beyond the addition of specific antioxidants, the prevention of oxidative protein damage involves the careful control of a number of factors throughout the manufacturing... 

GAPDH is inhibited to more than 80 % by a toxic dose of paracetamol. It seems likely that the initiating events are chemical interactions and protein damage and that gene changes may arise later, as a response and as part of the repair processes. 

Buss IH, Senthilmohan R, Darlow BA, MogridgeN, Kettle AJ, Winterboum CC (2003) 3-Chlorotyrosine as a Marker of Protein Damage by Myeloperoxidase in Tracheal Aspirates from Preterm Infants Association with Adverse Respiratory Outcome. Pediatr Res 53 455... 

---