Protein structure science

Jansy, B. (1988). Exploiting the insights from protein structure. Science 240, 722 723. 

Li FI, Winfreen N and Tang C 1996 Emergence of preferred structures in a simple model of protein folding Science 273 666-9... 

Beratan D N, Betts J N and Onuchic J N 1991 Protein electron transfer rates set by the bridging secondary and tertiary structure Science 252 1285-8... 

Fig, 10.25 The six environment categories used by the 3D profiles method. (Figure adapted from Bowie j U, R Liith. and D Eisenberg 1991. A Method to Identify Protein Sequences That Fold into a Known Three-Dunensinnal Structure. Science 253 164-170.)... 

Li H, R Helling, C Tang and N Wingreen 1996. Emergence of Preferred Structures in a Simple Model of Protein Folding. Science 273 666-669. 

Sanchez K and A Sali 1998. Large-scale Protein Structure Modelling of the Saccharomyces cerevi. Genome. Proceedings of the National Academy of Sciences USA 95 13597-13602. 

B and W J Howe 1991. Computer Design of Bioactive Molecules - A Method for Receptor-Based Novo Ligand Design. Proteins Structure, Function and Genetics 11 314-328. i H L 1965. The Generation of a Unique Machine Description for Chemical Structures - A hnique Developed at Chemical Abstracts Service. Journal of Chemical Documentation 5 107-113. J 1995. Computer-aided Estimation of Symthetic Accessibility. PhD thesis. University of Leeds, itan R, N Bauman, J S Dixon and R Venkataraghavan 1987. Topological Torsion A New )lecular Descriptor for SAR Applications. Comparison with Other Descriptors. Journal of emical Information and Computer Science 27 82-85. 

JU Bowie, R Liithy, D Eisenberg. A method to identify protein sequences that fold into a known three-dimensional structure. Science 253 164-170, 1991. 

Wiithrich, K. Protein structure determination in solution by nuclear magnetic resonance spectroscopy. Science 243 45-50, 1989. 

An aerial view of the European Synchrotron Radiation Facility at Grenoble, France, an advanced source of synchrotron x-ray radiation for use in the study of protein structure, as well as for use in the physical and material sciences. The synchrotron radiation is produced in the circular building in the lower left of the photograph. (Courtesy of ESRF.)... 

Noble ME, Endicott JA, Johnson LN (2004) Protein kinase inhibitors insights into drug design from structure. Science 303 1800-1805... 

There has been considerable and continuing investment in e-science and Grid-based computing around the world. Of particular interest for protein crystallography is the e-HTPX project funded by the UK research councils (http //www.e-htpx.ac.uk). The aim of e-HTPX is to unify the procedures of protein structure determination into a single all-encompassing interface from which users can initiate, plan, direct, and document their experiment either locally or remotely from a desktop computer. 

Figure 48-1. Molecular features of collagen structure from primary sequence up to the fibril. (Slightly modified and reproduced, with permission, from Eyre DR Collagen Molecular diversity in the body s protein scaffold.Science 1980 207 1315. Copyright 1980 by the American Association for the Advancement of Science.)...

Lefczynski, J. F. and Rose, G. D., Loops in globular proteins a novel category of secondary structure, Science, 234, 849, 1986. 

Burley SK, Petsko GA. Aromatic-aromatic interactions a mechanism of protein structure stabilization. Science 1985 229 23-28. 

A fundamental goal of research in the biological sciences is to understand protein structure. In theory, protein sequence information can be inferred from the fast growing volume of DNA sequence data [1] but predicting the three-dimensional structure of a protein from its sequence remains an open and important problem [2 1]. Part of the difficulty in solving this problem is due to the fact that many of the existing techniques rely on our knowledge of previously determined structures which, compared to sequence data, is relatively limited. 

Baker D, Sali A (2001) Protein structure prediction and structural genomics. Science 294(5540) 93-96... 

Schueler-Furman O et al (2005) Progress on modeling of protein structures and interactions. Science 310(5748) 638-642... 

Holmquist, M. (2000) Alpha/beta-hydrolase fold enzymes structures, functions and mechanisms. Current Protein Peptide Science, 1, 209-235. 

Eggers, D.K. and Valentine, J.S. (2001) Molecular confinement influences protein structure and enhances thermal protein stability. Protein Science, 10, 250-261. 

Almost all products of modern pharmaceutical biotechnology, be they on the market or likely to gain approval in the short to intermediate term, are protein based. As such, an understanding of protein structure is central to this topic. A comprehensive treatment of the subject would easily constitute a book on its own, and many such publications are available. The aim of this chapter is to provide a basic overview of the subject in order to equip the reader with a knowledge of protein science sufficient to understand relevant concepts outlined in the remaining chapters of this book. The interested reader is also referred to the Further reading section, which lists several excellent specialist publications in the field. Much additional information may also be sourced via the web sites mentioned within the chapter. 

Petrey, D. and Honig, B. 2005. Protein structure prediction inroads to biology. Molecular Cell 20(6), 811-819. Radford, S. 2000. Protein folding progress made and promises ahead. Trends in Biochemical Sciences 25(12), 611-618. 

A. A. Kossiakoff, Tertiary Structure Is a Principal Determinant to Protein Deamidation , Science 1988, 240, 191 -194. 

Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999) Regulation of transcription by a protein methyltransferase. Science 284 2174-2177 Chubb JR, Boyle S, Perry P, Bickmore WA (2002) Chromatin motion is constrained by association with nuclear compartments in human cells. Curr Biol 12 439-445 Croston GE, Kadonaga JT (1993) Role of chromatin structure in the regulation of transcription by RNA polymerase II. Curr Opin Cell Biol 5 417-423... 

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