Prostate drug-induced

Prentice DE, Meikle AW (1995) A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man. Human Exp Toxicol 14 562-572 Bosland MC (1996) Hormonal factors in carcinogenesis of the prostate and testis in humans and in animal models. In Huff J, Boyd J, Barett JC (eds) Cellular and Molecular Mechanisms of Hormonal Carcinogenesis Environmental influences. Wiley-Liss, New York, pp 309-352... 

Trihexyphenidyl is contraindicated in patients with narrow-angle glancoma becanse drug-induced cycloplegia and mydriasis may increase intraocnlar pressure in patients with cardiac disorders, arteriosclerosis, renal disorders, hepatic disorders, hypertension, obstructive G1 or genitourinary tract disease, or snspected prostatic hypertrophy becanse the drug may exacerbate these conditions. 

Royle, J.S., Ross, J.A., Ansell, 1., Bollina, R, Tulloch, DJ., and Habib, F.K. (2004). Nitric oxide donating nonsteroidal anti-inflammatory drugs induce apoptosis in human prostate cancer cell systems and human prostatic stroma via caspase-3. J. Urol. 772(1), 338-344. 

There is a higher incidence of impaired sexual function in men who take finasteride compared with placebo (58,59). The incidence of erectile dysfunction has been estimated at 5% (60), but it is difficult to estimate, since in many users of the drug other causes are present, including advanced age, heart disease, diabetes, hypertension, smoking, and hypercholesterolemia. Benign prostatic hyperplasia itself can also aggravate or even induce erectile dysfunction. A questionnaire study in New Jersey... 

Hall, A. 1996. Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells. Anticancer Drugs 7, 12-20. 

Either the catalytic subunit or both subunits are overexpressed in several drug-resistant human cancer cells such as cisplatin-resistant ovarian cancer cells and melphalan-resistant prostate cancer cells, suggesting that elevated production of glutathione may induce drug-resistance mechanisms in these cancer cells (Figure... 

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