Prostanoid receptors

Prostanoids. Table 1 Pharmacological properties of prostanoid receptors... 

A second pathway, uveoscleral outflow, comprises the other 20% of aqueous humor drainage. In the uveoscleral pathway, aqueous humor exits the anterior chamber through the iris root and through spaces in the ciliary muscles, which then drains into suprachoroidal space. Uveoscleral outflow can be pharmacologically modulated by adrenoceptors, prostanoid receptors, and prostamide receptors.4,10,12-15... 

Herve, M., et al. (2003). Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion. Eur. J. Immunol 33, 2764-72. 

Narumiya, S., and EitzGerald, G. A. (2001) Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest. 108, 25-30. 

Capra, V., Habib, A., Accomazzo, M. R., et al. (2003) Thromboxane prostanoid receptor in human airway smooth muscle cells a relevant role in proliferation. Eur. J. Pharmacol. 474, 149-159. 

Citro, S., Ravasi, S., Rovati, G. E., and Capra, V. (2005) Thromboxane prostanoid receptor signals through G(i) protein to rapidly activate extracellular signal-regulated kinase in human airways. Am. J. Respir. Cell Mol. Biol. 32,326-333. 

The prostanoid receptors are G-protein coupled rhodopsin-type receptors with seven transmembrane domains [6] (Fig. 3). The overall homology among the receptors is not high, though these receptors conserve the important amino acid sequences in several regions, especially in the seventh transmembrane domain. 

Fig. 3. Prostanoid receptor. Reproduced with permission from Ref. [6d]. Copyright 2001 Tokyo Kagaku Dojin.

Recently, new fluorinated prostanoids that utilized unique properties of fluorine have been developed in accord with rapid advances in molecular biology on prostanoid receptors. This chapter reviews the synthesis and pharmacological properties of novel fluorinated prostanoids in development. 

Since molecular cloning of the prostanoid receptors, the research in this field has been evolved quite fast. Information obtained from the studies on the receptor... 

M. Kiriyama, F. Ushikubi, T. Kobayashi, M. Hirata, Y. Sugimoto, S. Nammiya, Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells, Br. J. Pharmacol. 122 (1997) 217. 

N. C. Day, S.D. Collins, S. Bingham, A.W. Wilson, D. Elliot, R. Birch, P. Anand, Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury A time-course study, BMC Neurol. 6 (2006) 1. 

N.A. Sharif, J.Y. Crider, T.L. Davis, AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation Comparison with some purported FP antagonists, J. Pharm. Pharmacol. 52 (2000) 1529. 

Prostanoid receptors and their signaling pathways. fMLP, formylated MetLeuPhe, a small peptide receptor PLC-3, phospholipase C-3. All of the receptors shown are of the 7-transmembrane, G-protein coupled type. The terms "relaxant," "contractile," and "inhibitory" refer to the phylogenetic characterization of their primary effects. AII EP3 isoforms couple through G but some can also activate Gs or G12/13 pathways. RhoGEF, rho guanine nucleotide exchange factor. See text for additional details. 

Breyer RM et al Prostanoid receptors Subtypes and signaling. Annu Rev Pharmacol Toxicol 2001 41 661. [PMID 11264472]... 

Leonhardt A et al Expression of prostanoid receptors in human ductus arteriosus. Br J Pharmacol 2003 138 655. [PMID 12598419]... 

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