Prostanoid fluorinated

Fluorine Substitution of Prostanoids. Fluorination of prostaglandins, prostacyclins and thromboxanes has led to exciting and useful modifications of activity. The biosynthetic pathway of these compounds begins with arachidonic acid (14). 

Recently, new fluorinated prostanoids that utilized unique properties of fluorine have been developed in accord with rapid advances in molecular biology on prostanoid receptors. This chapter reviews the synthesis and pharmacological properties of novel fluorinated prostanoids in development. 

In this chapter, the recent development of the fluorinated prostanoids, which take advantage of the unique properties caused by fluorine atoms, was introduced. It is remarkable that a subtle change in structures of a series of compounds markedly... 

In the synthesis of fluorinated prostanoids, there are still limited methods to introduce fluorine atoms selectively to the target molecule. It is hoped that the development of new fluorination reactions will contribute to the progress on the prostanoid research, and possibly discovery of novel drugs addressing unmet medical needs in future. 

Fluorinated Prostanoids Development of Tafluprost, a New Anti-glaucoma Agent... 

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