Airway smooth muscle cells

Joubert P, Lajoie-Kadoch S, Labonte I, et al. CCR3 expression and function in asthmatic airway smooth muscle cells. J Immunol 2005 175(4) 2702-2708. 

El-Shazly A, Berger P, Girodet PO, et al. Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol 2006 176(3) 1860-1868. 

Hirshman CA, Zhu D, Panettieri RA, Fmala CW. Actin depolymerization via the beta-adrenoceptor in airway smooth muscle cells a novel PKA-independent pathway. Am J Physiol Cell Physiol 2001 281(5) C1468-1476. 

Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adre-nergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995 13(1) 25—33. 

Gounni AS. Hamid Q. Rahman SM. Hoeck J. Yang J. Shan L IL-9-mediated induction ofeotaxinl/CCLll in human airway smooth muscle cells. J Immunol 2004 173 2771-2779. 

Rahman MS, Yang J, Shan LY, Unruh H, Yang X, Halayko AJ, Gounni AS IL-17R activation of human airway smooth muscle cells induces CXCL-8 production via a transcriptional-dependent mechanism. Clin Immunol 2005 115 268-276. 

Although previous studies suggested a basal tone of smooth muscle mediated by histamine binding to HRl, constitutive intrinsic activity of the HRl without any occupation by histamine might be more relevant. Histamine also induces proliferation of cultured airway smooth muscle cells [63]. 

Capra, V., Habib, A., Accomazzo, M. R., et al. (2003) Thromboxane prostanoid receptor in human airway smooth muscle cells a relevant role in proliferation. Eur. J. Pharmacol. 474, 149-159. 

Mizuta et al Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2008 294 L523. 

Like the 5-HT1A receptor (see Section 2.1), the 5-HT2A receptor can regulate several transport processes. The 5-HT2A receptor activates the type 1 sodium-proton exchanger (NHE-1) in renal mesangial cells (187,227) and vascular smooth muscle cells (222), the Na+K+-AIPase (sodium pump) in airway smooth muscle cells (228), and the Na+/K+/2Cr cotransporter when 5-HT2A receptor transfected... 

Rhoden KJ, Dodson AM, Ky B. Stimulation of the Na(+)-K(+) pump in cultured guinea pig airway smooth muscle cells by serotonin. J Pharmacol Exp Ther 2000 293 107-112. 

Mechanical forces that occur during breathing have been reported to be capable of causing failure of the ECM at loci of stress and to contribute to the progression of emphysema. Chronic asthma is associated with a marked increase in the airway wall thickness, and an increased muscle cell mass. Hyperplasia of airway smooth muscle cells in vivo is probably accompanied by a change in contractile capacity and appears to be a consequence of the increased forces required for breathing through narrowed airways. 

Airway smooth muscle cells isolated from canine tracheae and bronchi subjected to cyclic strain exhibit increased cell number and DNA synthesis in cell culture. The content of total cellular protein, especially contractile proteins including myosin, myosin light chain kinase, and desmin, was increased compared to cells cultured under static conditions. 

Stretch-induced mechanical loading also appears to effect secondary messenger activation in airway smooth muscle cells. A 20% single static stretch of rat pulmonary smooth muscle cells increases both Ca+2 influx and efflux. Mechanical strain rapidly increases tyrosine phosphorylation of ppl25FAK and paxillin in airway smooth muscle cells cultured in type I collagen matrices. Tyrosine kinase inhibitors hindered strain-induced reorientation and elongation of airway smooth muscle cells. 

Smith PG, Garcia R, Kogerman L. Strain reorganizes focal adhesions and cytoskele-ton in cultured airway smooth muscle cells. Exp Cell Res. 1997 232 127-136. 

Hirst, S.J., Barnes, P.J. andTwort, C.H.L. (1992). Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor. Am. J. Respir. Cell Mol. Biol. 7, 574-581. 

Kotlikoff, M.I., (1988). Calcium currents in isolated canine airway smooth muscle cells. Am. J. Physiol. 254, C793-C801. 

Small, RC., Foster, RW. (1988). Electrophysiology of the airway smooth muscle cell. In Asthma Basic Mechanisms and clinical Management (eds P.J. Barnes, I.W. Rodger and N.C. Thomson), pp. 35-56, Academic Press, London. 

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