Pharmacologic modulation

Lee, B.S., Chen, J., Angelidis, C., Jurivich, D.A., Morimoto, R.l. (1995). Pharmacological modulation of heat shock factor 1 by antiinflammatory drug results in protection against stress-induced cellular damage. Proc. Natl. Acad. Sci. USA 92, 7207-7211. 

Pharmacological modulation of GABA -receptor and glycine-receptor channels... 

A second pathway, uveoscleral outflow, comprises the other 20% of aqueous humor drainage. In the uveoscleral pathway, aqueous humor exits the anterior chamber through the iris root and through spaces in the ciliary muscles, which then drains into suprachoroidal space. Uveoscleral outflow can be pharmacologically modulated by adrenoceptors, prostanoid receptors, and prostamide receptors.4,10,12-15... 

Shivkumar, K. and Valderrabano, M. (2004) Use of potassium channel openers for pharmacologic modulation of cardiac excitability. Journal of Cardiovascular Electrophysiology, 15, 821-823. 

Goff WL, Guerin M, Chapman JM. Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyshpidemia. Pharmacol Ther 2004 101 17-38. 

PHARMACOLOGICAL MODULATION OF DIARRHEA AND CONSTIPATION BY MECHANISMS THAT DO NOT DIRECTLY AFFECT MOTILITY ... 

Bender PE, Lee JC., eds. Pharmacological modulation of interleukin-1 (1989). Annual reports in medicinal Chemistry-25. Johns. Section IV-Metabolic diseases and endocrine function. Chapter 20. 

Different K+ channels can be distinguished by their characteristic electrophysiological properties as well as differential sensitivities to pharmacological modulation. For example, Kv channels are blocked by 4-aminopyridine (4-AP), tetraethylammonium (TEA) and millimolar concentrations of Ba. In contrast, Kir channels are also blocked by TEA but show selective sensitivity to sub-millimolar concentrations of Ba2+. Furthermore, certain peptide toxins (e.g. dendrotoxins, tertiapin) can sometimes discriminate between K+ channels belonging to the same family. The K+ channel openers diazoxide, pinacidil and cromakalim (see below) act on the three SUR subunits with a differential order of potency thereby affecting KATP channels in a cell type-specific manner (Yokoshiki et al., 1998). 

Y7. Young, P. R., Pharmacological modulation of cytokine action and production through signaling pathways. Cytokine Growth Factor Rev. 9, 239-257 (1998). 

Watala C, Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus. Curr Pharm Des 2005 I 1 233 1-2365. Review. 

Knoflach, E, Benke, D., Wang, Y., Scheurer, L., Luddens, H., Hamilton, B. J., Carter, D. B., Mohler, H., and Benson, J. A. (1996). Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol. Pharmacol. 50, 1253—1261. 

Pharmacologic Modulation with Dopamine-related Drugs... 

Hinas, R., and Yarom, Y. Oscillatory properties of guinea-pig inferior olivary neurones and their pharmacological modulation an in vitro study. J Physiol 1986, 376 163-182. 

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