Prostaglandin therapy

Peled N et al Gastric-outlet obstruction induced by prostaglandin therapy in neonates. N Engl J Med 1992 327 505. [PMID 1635565]... 

The cure rate for gastric and duodenal ulcers is comparable to the results with H2-receptor antagonists (44— 46). Relapses appear to be fewer with prostaglandin therapy (44,45). Healing of duodenal ulcers refractory to H2-receptor antagonists has been described. 

Prostaglandin therapy can cause electroencephalo-graphic abnormalities (105). Convulsions, which occur occasionally, are a particular risk in epileptic patients (5,104,105). The combination of prostaglandins and oxytocin can be complicated by tonic-clonic seizures (106). 

Kaufman MB, El-Chaar GM. Bone and tissue changes following prostaglandin therapy in neonates. Ann Pharmacother 1996 30(3) 269-77. 

Misoprostol has several therapeutic uses, including the treatment of gastroduodenal ulceration and labor induction and has the advantage of being relatively inexpensive and stable enough to be stored at room temperature. Prostaglandin therapy for the induction of labor is a well-established practice, and misoprostol has been compared with dinoprostone and also oxytocin. It was found to be equieffective with oxytocin (325)and more effective than dinoprostone (326). It was also shown to be effective in 92% of women in combination with tamoxifen (327). However, mi-... 

This classification is important to people involved in pharmaceutical research. An expert in peptide or prostaglandin chemistry will be primarily concerned with the various chemical manipulations that can be performed on these molecules and will rely on someone else to screen them for effects against the various illnesses susceptible to peptide or prostaglandin therapy. On the other hand, the chemical classification allows an excellent overview of all the congeners and analogues derived from an initial lead and thus facilitates structure-activity considerations. 

Susanna, R, Jr, Chew, P and Kitazawa, Y (2002) Current status of prostaglandin therapy latanoprost and unoprostone. Surv Ophthalmol, Al, S97-S104. 

Bismuth Subsalicylate. (2-Hydroxybenzoato-0 )-oxobismuth [14882-18-9] (Pepto-Bismol) maybe made by the process described in Reference 10. Bismuth subsaHcylate has been shown to bind toxins produced by several bacterial strains. It may also act as a result of its saHcylate component on prostaglandin formation and have specific intestinal antisecretory activity. It has been found to be effective in the prevention and therapy of... 

Li+ also inhibits several hormone-stimulated adenylate cyclases which, in some cases, appear to be related to side effects of Li+ therapy. For instance, Li+ inhibits the hydro-osmotic action of vasopressin, the antidiuretic hormone which increases water resorption in the kidney [136]. This effect is associated with polyuria, a relatively harmless side effect sometimes experienced with Li+ treatment, which arises from the inability of the kidney to concentrate urine. Li+ has been shown to inhibit vasopressin-stimulated adenylate cyclase activity in renal epithelial cells. Additionally, Li+ is reported to enhance the vasopressin-induced synthesis of prostaglandin E2 (PGE2) in vitro in kidney. PGE2 inhibits adenylate cyclase activity by stimulation of Gj, and, therefore, this effect may contribute to the Li+-induced polyuria. 

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