6-Propyl-2-thiouracil

Propyl iodide, i48 Propyl mercaptan, pi 98 6-Propyl-2-thiouracil, hi 40 Pseudocumene, t358 Pyrene, b52... 

Abstract This presentation is a brief review on the resnlts of our work on iodine interaction with thioamides, selenoamides and amides. The thioamides, benzothia-zole-2-thione (BZT) (1), 6-n-propyl-2-thiouracil (PTU) (2), 5-chloro-2-mercap-tobenzothiazole (CMBZT) (3), N-methyl-benzothiazole-2-thione (NMBZT) (4), benzimidazole-2-thione (BZIM) (5), thiazolidine-2-thione (TZD) (6), 2-mercapto-pyridine (PYSH) (7), 2-mercapto-nicotinic acid (MNA) (8), 2-mercapto-benzoic acid (MBA) (9) and 2-mercapto-pyrimidine (PMT) (10) react with producing three type of complexes of formulae [(HL)IJ(l2) (HL= thioamide and n= 0, 1), [(HL) [I3 ] and [(HL-L)]+[l3 ]. The interaction of seleno-amides, derived from, 6-n-propyl-2-thiouracil (RSelJ) (R= Me- (11), Et- (12), n-Pr- (13) and i-Pr- (14)) with I, have also been studied and produced the complexes [(RSeU)IJ of spoke structure. These complexes are stable in non-polar solvents, but they decompose in polar solvents, producing dimeric diselenide compounds or undertake deselenation. 

SWV has been applied to study electrode reactions of miscellaneous species capable to form insoluble salts with the mercury electrode such as iodide [141,142], dimethoate pesticide [143], sulphide [133,144], arsenic [145,146], cysteine [134, 147,148], glutathione [149], ferron (7-iodo-8-hydroxyquinolin-5-sulphonic acid) [150], 6-propyl-2-thiouracil (PTU) [136], 5-fluorouracil (FU) [151], 5-azauracil (AU) [138], 2-thiouracil (TU) [138], xanthine and xanthosine [152], and seleninm (IV) [153]. Verification of the theory has been performed by experiments at a mercury electrode with sulphide ions [133] and TU [138] for the simple first-order reaction, cystine [134] and AU [138] for the second-order reaction, FU for the first-order reaction with adsorption of the ligand [151], and PTU for the second-order reaction with adsorption of the ligand [137]. Figure 2.90 shows typical cathodic stripping voltammograms of TU and PTU on a mercuiy electrode. The order of the... 

Fig. 2.91 The influence of acetonitrile on the net SW peak currents A/p (left axis, curve 1) and peak potential (right axis, curve 2) of 6-propyl-2-thiouracil (PTU). The experimental conditions are c(PTU) = 1 X mol/L, /= 50 Hz, sw = 20 mV, A = 2 mV, /delay = 10 s, face = -0.10 V (with permission from [136])...

Propyl-2-thiouracil (propacil, propyail) [51-52-5] M 170.2, m218-220 , 218-220 . Purified by recrystn from H2O (sol in 900 parts at 20°, and 100 parts at 100°). UV, MeOH Xmax 277nm. [Anderson et al. JACS 67 2197 1945, Vanderhaegue Bull Soc Chim Beiges 59 689 1950]. 

In rats equilibrated with radioiodine-labelled T4 or T3 roughly half of the radioactivity appears as I- in the urine and the other half as free iodothyronines in the feces [12]. Treatment of the rats with 6-propyl-2-thiouracil (PTU) results in a marked decrease in urinary radioactivity and a reciprocal increase in fecal clearance [12]. Also, in humans, PTU has been shown to inhibit peripheral iodothyronine deiodination besides its well-known effect on thyroid hormone biosynthesis [13]. Compared with the rat, deiodination is an even more important pathway for the clearance of thyroid hormone in man as evidenced by the greater proportion undergoing urinary clearance [2]. Furthermore, estimation of iodothyronine turnover kinetics in humans has demonstrated that a major fraction of T4 disposal is accounted for by plasma production rates of T3 and rT3 [2,3],... 

PROPIL-TIOURACILE (ITAIJAN) PROPYCIL 6-PROPYL-2-THIO-2,4(lH,3H)PYRIMIDINEDIONE PROPYL-THIORIST PROPYLTHIOURACIL 4-PROPYL-2-THIOURACIL 6-N-PROPYLTHIOURACIL 6-N-PROPYL-2-THIOURACIL PROPYL-THYRACIL PROPYTHIOURACIL PROTHIUCIL PROTHIURONE... 

PROPYL-THIORIST see PNXOOO PROPYLTHIOURACIL see PNXOOO 4-PROPYL-2-THIOURACIL see PNXOOO 6-PROPYL-2-THIOURACIL see PNXOOO 6-N-PROPYLTHIOURACIL see PNXOOO 6-N-PROPYL-2-THIOURACIL see PNXOOO PROPYL-THYRACIL see PNXOOO n-PROPYLTRICHLOROSILANE see PNX250 PROPYLTRICHLOROSILANE pOT) see PNX250 n-PROPYL-3,4,5-TRIHYDROXYBENZOATE see PNM750... 

Just as in olfaction, a number of clues pointed to the involvement of G proteins and, hence, 7TM receptors in the detection of bitter and sweet tastes. The evidence included the isolation of a specific G protein a subunit termed gustducin, which is expressed primarily in taste buds (Figure 32.13). How could the 7TM receptors be identified The ability to detect some compounds depends on specific genetic loci in both human beings and mice. For instance, the ability to taste the bitter compound 6- -propyl-2-thiouracil (PROP) was mapped to a region on human chromosome 5 by comparing DNA markers of persons who vary in sensitivity to this compound. 

Huopalahti and Henion " reported anabolic steroid extraction from bovine tissues. SFE was performed with CO2 at 60°C and 405 bar, with analytes collected in precooled methanol and quantitated using LC-MS analysis. Residues of 2-thiouradl, 6-methyl-2-thiouradl, 6-propyl-2-thiouracil, and 6-phenyl-2-thiouracil in bovine muscle tissues were extracted with SC CO2 and analyzed using GC-MS. ... 

PropyfthiouradI, USP. Propylthiouracil. 6-propyl-2-thiouracil (Propacil), is a. stable, white, crystalline powder with a biner taste. It is slightly soluble in water but readily soluble in alkaline solutions (salt formation). 

The extraction of some anabolic steroids directly from bovine tissue was reported by Huopalahti and Henion (108). SFE was performed with CO2 at 60 °C and 405 bar and anlytes were collected in precooled methanol. The quantitation of the analytes was carried out with HPLC-atmospheric pres-sure-ClMS. The detection limit was 100 pg/mL. Bovine muscle tissue was also used for the determination of residues of 2-thiouracil, 6-methil-2-thio-uracil, 6-propyl-2-thiouracil, and 6-phenyl-2-thiouracil by GC-MS (109). The analytes, extracted with acetonitrile from homogenized beef muscle, were spiked with a surrogate compound, 5-ethyl-2-thiouracil, transferred to a column and methylated. The products were extracted with acetonitrile or supercritical CO2. 2,4,5-Triclorophenoxyacetate was used as the internal standard. 

Both AMI and MNDO methods correctly predict the predominance of the oxo-thione form for A-monosubstituted 2-thiouracils in the gas phase (89JCS(P2)1507). The gas phase calculated relative stabilities, proton affinities and aqueous phase calculated acidity constants predicted the higher stability of the oxo-thione form of 6-propyl-2-thiouracil compared to the hydroxy(thiol) tautomer (04JST(679)33). 

Thionamides are the most important class of antithyroid compounds in clinical practice used in nondestructive therapy of hyperthyroidism. These agents are potent inhibitors of TPO, which is responsible for the iodination of tyrosine residues of thyroglobulin and the coupling of iodotyrosine residues to form iodothyronines. These drugs have no effect on the iodide pump or on thyroid hormone release. The most clinically useful thionamides are thioureylenes, which are five- or six-membered heterocyclic derivatives of thiourea and include the thiouracil 6-n-propyl-2-thiouracil (PTU) and the thioimidazole 1-methyl-2-mercaptoimidazole (methimazole, Tapazole, MMI). The uptake of these drugs into the thyroid gland is stimulated by TSH and inhibited by iodide. 

In this paper, we briefly review the results of our work on the iodine interaction with the thioamides benzothiazole-2-thione (BZT) (1), 6-n-propyl-2-thiouracil (PTU) (2), 5-chloro-2-mercaptobenzothiazole (CMBZT) (3), N-methyl-benzothia-zole-2-thione (NMBZT) (4), benzimidazole-2-thione (BZIM) (5), thiazohdine-2-thione (TZD) (6), 2-mercapto-pyridine (PYSH) (7), 2-mercapto-nicotinic acid (MNA) (8),... 

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